Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of M reaches milestone in diabetes research using pig islets

20.02.2006


Research offers hope to increase islet supply to cure type 1 diabetes

Researchers at the University of Minnesota’s Diabetes Institute for Immunology and Transplantation have successfully reversed diabetes in monkeys using transplanted islet cells from pigs.

Survival of pig islet transplants was made possible with a novel immunosuppressive protocol. Graft survival did not require genetic modification of donor pigs or coating or encapsulation of donor islets.



Researchers have already had success reversing type 1 diabetes in humans through islet transplantation, however, the demand for islet cells grossly outweighs the supply. In order to make islet transplantation a viable solution for the tens of thousands of people with difficult-to-manage diabetes, a safe and reliable source of islet cells must be found.

"These results suggest it is feasible to use pig islet cells as a path to a far-reaching cure for diabetes," said Bernhard J. Hering, M.D., associate professor of surgery and lead investigator. "Now that we have identified critical pathways involved in immune recognition and rejection of pig islet transplants, we can begin working on better and safer immunosuppressant therapies with the eventual goal of bringing the treatment to people."

This unprecedented progress on islet xenotransplantation will be released online Feb. 19, 2006 in the medical journal, Nature Medicine. If research continues to be successful, Hering believes it may be possible to start clinical trials in humans in the next three years.

To begin working toward the goal of using this technology to help people, Spring Point Project, a non-profit corporation, has taken concrete steps to build and operate biosecure barrier facilities to raise high-health pigs for planned pig islet transplant trials in humans.

Since it will take time to build biosecure facilities that meet the federal requirements for using animal tissues in humans, the Spring Point Project will proceed on a parallel track with the research at the University. The goal is to have suitable donor pigs available by the time the University has refined the immunosuppressive treatment to a point that makes it safe for clinical trials to begin.

Islet transplants seek to address an unmet medical need in people with type 1 and possibly type 2 diabetes who suffer frequent acute and severe chronic complications. The process is performed by isolating islet cells from a donor pancreas and transplanting them into the portal vein of the liver in people with diabetes. If successful, transplanted islets will sense blood glucose levels on a minute-to-minute basis and release the appropriate amount of insulin to achieve tight blood glucose control. Insulin injections are no longer needed in recipients of successful transplants.

Transplantation also offers hope in reducing the risk of developing debilitating secondary complications of diabetes, such as damage to the heart and blood vessels, eyes, nerves, and kidneys.

Sara Buss | EurekAlert!
Further information:
http://www.umn.edu

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>