Models could help speed discovery of new drugs
This GPCR’s specific function is still unknown. The database could help scientists determine the function of receptors like this one, potentially uncovering new drug targets.
In an important step toward accelerating drug discovery, researchers have created computer models of more than 900 cell receptors from a class of proteins known to be important drug targets. The models, which are now freely available to noncommercial users, promise to help scientists narrow their research inquiries, potentially speeding up the discovery of new drug compounds. The research appears in the February 17, 2006 issue of the Public Library of Science Computational Biology.
"This is the first time anyone has modeled them all with an algorithm that improves the accuracy of the structure," said Jeffrey Skolnick Georgia Research Alliance Eminent Scholar in Computational Systems Biology at the Georgia Institute of Technology. "I think its going to have significant impact, because its a major class of drug design."
David Terraso | EurekAlert!
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