The Dermatochemistry laboratory of the University Louis Pasteur’s Institute of Chemistry (Strasbourg 1) becomes a partner in the integrated European research project Sens-it-iv whose aim is to develop alternative methods to animal testing in the area of allergy.
Even though animal experimentation remains, for the moment, the most reliable way of testing the allergenic potential of a chemical substance, the wish of the European Union is to gradually reduce the number of animals used in toxicity tests. In 1996, a EU Directive on the protection of animals used for experimental purposes prohibits their use when valid, alternative testing methods exist. However, if the REACH -Registration, evaluation and authorisation of chemicals – legislation is instituted, 3000 chemical products marketed in Europe will have to be evaluated for their toxicological properties. (The objective of REACH is to ask the manufacturers to prove that the products they put on the market are harmless). In this context, it is of utmost importance therefore, to develop alternative strategies based on cell or tissue culture or computer modelling.
The objective of the Sens-it-iv project, which brings together 28 universities, institutes, companies and organisations, is to develop alternative in vitro methods that are able to evaluate the allergenic potential of a chemical substance without having to resort to animal testing. The ULP dermatochemistry laboratory, directed by Professor Jean-Pierre Lepoittevin, is the only chemistry laboratory taking part in the Sens-it-iv project. Its role (dedicated mostly to organic chemistry) will be to evaluate the chemical reactivity of different molecules and to study the reaction mechanisms between allergens (foreign substances capable of triggering an allergic reaction in the body) and cutaneous biomolecules (skin proteins). The results from each partnering laboratory will be gathered and pooled together in order to determine the structure and action of each chemical substance using the technique of bioinformatic simulation to ascertain their toxicity without using the animal experimentation model. The development of these alternative research methods concerns both contact allergens and respiratory allergens. Sens-it-iv takes on its full meaning given the increasing incidence of allergies observed in the European population.
Maria Isabel Pellon Zarragoitia | alfa
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences