Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A step forward in the fight against bacterial infections

02.02.2006


Bacterial infections can strike anyone, and they can sometimes be fatal. Because more and more bacteria are becoming resistant to the pre-eminent remedy - antibiotics - the search for new remedies against bacterial infections is in high gear. Research by scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to Ghent University shows that certain mice, by nature, can withstand particular bacterial infections. Elucidation of the biological process that underlies this natural ability offers perspectives for the development of new therapeutics.



A cascade of reactions protects us against infections

Most of the time, our body can overcome bacterial infections. Only a limited number of bacteria can make us sick, but sometimes they can be fatal. In the US, about 200,000 people die from bacterial infections each year. Normally, our natural immune system bars bacteria from entering our body, or it renders them harmless. The aggressiveness of the bacteria, our general state of health, and the speed with which our immune system reacts determine whether or not we become sick after contact with a bacterium.


Upon contact with a bacterium, or a bacterial component, the immune system springs into action. One such component of the bacterial cell wall is LPS. The binding of LPS with its specific receptor in our immune system - TLR4 - initiates a long series of reactions that bring on an inflammation, which eliminates the bacteria from our body. Of course, this chain of reactions is strictly controlled, because excessive inflammation can lead to lethal shock.

Mice that are able to cope with acute inflammations

Tina Mahieu and her colleagues from the research group led by Claude Libert are working with mice that are not susceptible to toxic LPS. The VIB researchers have discovered the mechanism behind this insensitivity.

One of the steps in the process of inflammation following contact with LPS is a profuse production of type 1 interferons. These proteins play an important role in the regulation of immunity. The Ghent researchers administered 10 times the lethal dose of LPS to the mutant mice, without deadly consequences. This finding could not be attributed to an alteration in TLR4, but to a reduced production of type 1 interferons. To verify this, Mahieu and her colleagues administered these interferons preventatively to the mice - which made the animals susceptible to LPS once again. Thus, this research shows that the mice are no longer able to produce large quantities of type 1 interferons - with the consequence that an inflammation fails to arise, demonstrating the importance of type 1 interferons to the inflammation process. On the other hand, the mice produce just enough interferons to activate the immune system against the bacteria, so that the mice are protected against bacterial infections.

Another step forward in the battle against bacterial infections

The results of this research are very relevant to the quest for new therapeutics for bacterial infections. The mutant mice display a combination of important characteristics: they are resistant to LPS, but they still recognize and destroy pathogens. The limited quantity of type 1 interferons enables the mice to cope with a lethal shock resulting from inflammation, but this small quantity also ensures that immunity is preserved. A next step in combating bacterial infections is to uncover the mechanism behind this reduced production.

Ann Van Gysel | alfa
Further information:
http://www.vib.be

More articles from Life Sciences:

nachricht Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University

nachricht Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>