Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researcher examining malignant melanoma in horses

01.02.2006


Malignant melanoma is a dangerous, aggressive form of cancer and approximately 54,000 new cases are diagnosed every year, according to the American Cancer Society. Interestingly, there are many similarities between malignant melanoma in horses and malignant melanoma in people.



Recognizing the extraordinary opportunity for translational research that the disease represents, Dr. John L. Robertson, a professor in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech and director of the college’s Center for Comparative Oncology (CECO), has been looking at one experimental treatment.

During a presentation before a regional meeting of the American Cancer Society in Roanoke, Va., Robertson detailed some of the work he is doing with the use of Frankincense oil as a possible treatment for malignant melanoma in horses.


The risk factors for malignant melanoma in people and horses are very similar, according to Robertson. In people, risk factors include pale complexion and hair, exposure to excessive sunlight and sunburns and aging. Horses at risk also have a pale coat of grey to white and there seems to be a correlation to aging, which could be a result of chronic exposure to sunlight, he said. In each, the disease is an infiltrated pigmented malignancy that is difficult to manage. Conventional therapies include chemotherapy, radiation, immunotherapy, and surgery.

The disease often affects horses with the development of lesions on the lips, neck, and perineal area.

Robertson presented the story of Chili, a handsome, 11-year old Thoroughbred and champion jumper that was diagnosed with multi-centric malignant melanoma at the age of seven. Told by her local practitioner that there was not much that could be done for Chili and aware of Robertson’s interest in evaluating an experimental therapy, Chili’s owner asked if Robertson would work with Chili.

That experimental therapy involved the use of frankincense oil, a compound known as a valuable treatment for wounds for more than 2,000 years, and one people are reminded of every Christmas when they recall the Gifts of the Magi brought to the Christ-child.

Frankincense oil is a fragrant botanical oil distillate made from fermented plants, explains Robertson, who adds that it contains hundreds of constituents, including boswellic acid, a component that is known to have anti-neoplastic properties. Scientists have demonstrated that the oil has potent anti-inflammatory effects and anti-tumor properties when evaluated in tissue culture with tumors such as astrocytomas, melanomas, and fibrosarcomas. Furthermore, he said, it appears to have fairly selective anti-tumor activity and does not appear to disrupt normal cells. But much about how it affects actual cancer patients is unknown.

Chili’s experimental protocol involved daily injections of medicinal grade, sterile frankincense oil directly into his tumors and the application of oil on topical tumors, while Chili’s comfort and well-being was carefully maintained through pain and nutritional management, including copious amounts of his favorite peeled baby carrots and peppermints.

The lesions were observed, measured, photographed, and periodically biopsied, according to Robertson. Those tumor biopsies demonstrated that some small tumor cells were destroyed by the treatment and those treated topically were reduced in size. Unfortunately, however, Chili passed away on October 18, 2005 as a result of the progressive and relentless growth of the non-treated tumors.

Chili’s involvement with CeCO and the experimental protocol did result in some important achievements, according to Robertson.

"I think this research on frankincense oil suggests that this ancient medicine may have significant modern uses for chemotherapy of non-resectable malignancies," said Robertson, a professor in the Department of Biomedical Sciences and Pathobiology. "This research showed that equine melanomas respond to this therapy."

Information gleaned from this Phase I-II National Cancer Institute format clinical trial has supported the development of grant applications and helped in the treatment of five additional horses, Robertson said. A collaboration with the Clinical Research Program at Wake Forest University’s Comprehensive Cancer Center is being discussed.

Jeffrey Douglas | EurekAlert!
Further information:
http://www.vt.edu

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>