Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein holds back growth of head and neck tumors

01.02.2006


A protein associated with the growth of head and neck tumors may be a tumor suppressor that could prevent the spread of cancer when it is expressed above normal levels, according to a study published in the Feb. 1 issue of the Journal of the National Cancer Institute (JNCI).



The study, led by University of Pittsburgh School of Medicine professor of otolaryngology and pharmacology, Jennifer Grandis, M.D., is the first to show that the expression of a protein called STAT1 may play a vital role in preventing head and neck tumor growth. STAT1 belongs to a family of proteins called signal transducers and activators of transcription that have been linked to tumor progression in many cancers.

"While the activation of STAT1 has been associated with increased survival in breast cancer patients, its role in head and neck cancer has not been clearly understood," said Dr. Grandis. "Our study reveals that it is a critical survival pathway in head and neck cancer and that therapeutic strategies to restore its functioning may be of benefit to patients."


Dr. Grandis, who also is director of the Head and Neck Cancer Program at the University of Pittsburgh Cancer Institute (UPCI), and colleagues compared the expression of STAT1 in squamous cell carcinoma of the head and neck (SCCHN) tumors to its expression in normal tissue samples. They found that STAT1 was expressed in lower levels in the tumor cells than in the normal cells. And, when they chemically altered the expression of STAT1 to increase its levels, the cancer cells diminished and died.

To alter the expression of STAT1, the researchers treated cells with an agent that removes methyl groups and modifies gene expression. Some of the SCCHN cells were then treated with chemotherapy alone and others in combination with azacytidine, an agent that reversed the process and increased STAT1 production. Those cells treated with chemotherapy and azacytidine were more responsive to the treatment and more likely to stop growing and eventually die.

"When STAT1 signaling was silenced, the tumor cells grew indicating to us that its loss promotes cancer growth," said Dr. Grandis. "On the other hand, when the signaling was increased and combined with chemotherapy, cancer cells were more likely to die."

More than two-thirds of head and neck cancer patients have a locally advanced stage when diagnosed. The disease has a poor five-year survival rate even after treatment. Current treatment options are limited and often cause disabling side effects.

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>