Two independent research papers in the February 1 issue of G&D reveal that the Drosophila UNR protein is a novel regulator of X-chromosome dosage compensation in flies. Dosage compensation is the equalization of X-linked gene expression between males (which have one X chromosome in flies) and females (which have two X chromosomes in flies). Fruit flies accomplish this by increasing transcription of the single male X chromosome two-fold. Transcriptional upregulation of the Dros. male X chromosome is facilitated by the Dosage Compensation Complex (DCC). The DCC fails to assemble in female flies because a key subunit, male-specific lethal 2 (msl-2), is not produced.
Previous work identified the sex-lethal protein (dSXL) as a necessary repressor of msl-2 translation. New work from the labs of Drs. Fatima Gebauer (CRG-UPF) and Matthias Hentze (EMBL) identify the Drosophila homolog of the mammalian UNR protein as a co-factor required for SXL-mediated repression of msl-2 translation.
Dr. Gebauer points out that the "UNR is, therefore, an essential component of a translational control mechanism that prevents dosage compensation in female cells," and Dr. Hentze adds that "These new studies teach us how a protein that is expressed in both sexes can be used for an essential female-specific function. Learning more about how dSXL and UNR work together will instruct us on how cells control the key step of protein synthesis."
Heather Cosel | EurekAlert!
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Materials Sciences
08.12.2016 | Materials Sciences
08.12.2016 | Physics and Astronomy