Intracellular observation of RNA metabolism will help identify disease-associated RNAs
For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe–in real-time–the intricate activities of these special molecules that make them key players in managing some of the cells most basic functions. Researchers at the University of Pennsylvania School of Medicine who developed the new technology see this advance as one of the next logical steps in genomics research. Senior author James Eberwine, PhD, Professor of Pharmacology at Penn, and colleagues published their research this week in the Proceedings of the National Academy of Sciences.
"Now we have a workable system to understand all aspects of RNA metabolism in a cell," say Eberwine. "For the first time, we can study how manipulation of cellular physiology, such as administering a drug, changes RNA-binding protein and RNA interactions. This technology allows us to see that in real time in real cells."
Karen Kreeger | EurekAlert!
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