Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New biochip predicts evolution of inflammatory bowel disease

27.01.2006


The treatment of inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis, has very high costs and can include admissions and surgical interventions. Until now, there was no precise tools to predict the evolution and prognosis of these diseases. A new biochip, IBDchip, (Inflammatory Bowel Disease DNA Chip) is a pioneering programme which has the aim to have a direct influence in the quality of life of patients.



This chip has been created by the biotechnology enterprise Progenika Biopharma, and IDIBAPS-Hospital Clínic de Barcelona has led the multicentre study which demonstrates the improving of the prognosis and therapeutics applied to patients with inflammatory bowel disease. Dr. Miquel Sans, from the Gastroenterology Department of Hospital Clínic and collaborator of the IDIBAPS group Physiopatology of gastrointestinal lesions has been in charge of the coordination of the trial and has participated, along with Dr. Carlos Cara, of UCB Pharma, in the development of the diagnostic chip.

This study had the participation of 579 patients (335 of which with Crohn’s disease and 344 with ulcerous colitis), and of the Central University Hospital of Asturias, University Clinical Hospital of Santiago de Compostela and Lozano Blesa Clinical Hospital of Zaragoza.


IBDchip includes the 61 polymorphisms that the scientific literature has until now associated to the inflammatory intestinal disease, the predisposition to suffer from it and its possible evolution. This is an open tool that can be updated while new related mutations are identified. To perform this diagnostic test, which uses laser technology, only a small blood sample of the patient is needed. IBCchip has been developed in the framework of the collaboration agreement signed in march 2004 between IDIBAPS and Cooperative Research Association in Biosciences of Biscay (CIC BIOGUNE). The inflammatory intestinal disease has an important genetic component, and it is estimated that there are 10 or 15 new cases per 100,000 inhabitants and year. In Spain, there are approximately 100,000 affected patients.

According to the study promoted by IDIBAPS- Hospital Clínic, in the Crohn’s disease, this microchip permits to predict with precision the localisation and extension of the pathology, the risk of suffering from the perianal disease, fistula or abscess, the possible need for surgery or the probability of having associated extraintestinal manifestations. In the case of ulcerative colitis, the IBDchip provides a large precision in the determination of the extension of the lesion, the need for a colectomy and the probabilities of associated extraintestinal manifestations. All this permits a more individualised treatment, with the aim to improve the quality of life of the patients. Furthermore, we must also emphasize the potential reduction in the health expense associated to the inflammatory bowel disease. In order to improve the study of the possibilities offered by the new diagnostic tool, Dr. Miquel Sans, of IDIBAPS-Hospital Clínic has promoted the creation of an European network which will have the participation of centres of 8 countries and will coordinate two more validation studies, held in the United States and in Japan.

Àlex Argemí Saburit | alfa
Further information:
http://www.idibaps.ub.edu

More articles from Life Sciences:

nachricht Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden

nachricht The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>