Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tumor cell growth depends on interactions with its microenvironment

27.01.2006


An EU funded Specific Targeted Research Project (STREP) entitled "Tumor-Host Genomics" has been launched at the University of Helsinki, Finland. The Tumor-Host Genomics project links together the resources of five European leading-edge laboratories studying major signaling pathways in mesenchymal and hematopoietic cells, forming a concerted effort to understand tumor-host interactions, and to identify novel therapeutic targets.



The European Union will fund the project with a total of 2.7 million € during the next three years. The project is coordinated by Dr. Petri Salven from the University of Helsinki. The other participating principal investigators are Dr. Kari Alitalo and Dr. Jussi Taipale, also form the University of Helsinki, Dr. Peter ten Dijke from Leiden University Medical Center in the Netherlands, and Dr. Luigi Naldini from the San Raffaele Telethon Insitute for Gene Therapy in Italy.

In addition to oncogenic mutations that act cell-autonomously, tumor cell growth depends on interactions with its microenvironment. Tumor microenvironment consists of cells of hematopoietic and mesenchymal origin, including inflammatory cells, stem and progenitor cells, fibroblasts, endothelial cells and vascular mural cells. Tumor cell growth is known to depend on the interaction of tumor cells with such stromal cells. For example, growing tumor needs to recruit normal endothelial and vascular mural cells to form its blood vessels.


The Tumor-Host Genomics project will develop novel advanced functional genomics instruments, technologies and methods to study tumor-host interactions in cancer, and apply these techniques to the identification of molecules and processes in normal cells which could be targeted by novel anti-cancer therapeutic agents. The ultimate goal of the project is to unravel and validate new targets for anticancer therapy, and new strategies for delivering therapy to tumors.

"We are studying the molecular and cellular interactions between the normal, benign cells of the tumor microenvironment, and the cancer cells. These interactions represent an attractive target for cancer therapy, because normal cells are genetically stable, and would not be expected to develop resistance to therapeutic agents", says Dr. Salven, the coordinator for the project.

The principal investigators participating the Tumor-Host Genomics project:

Adjunct Professor, Academy Researcher Petri Salven, University of Helsinki, Biomedicum Helsinki, Finland
Expertise: stem cells and tumor angiogenesis, RNAi, imaging

Academy Professor Kari Alitalo, University of Helsinki, Biomedicum Helsinki, Finland
Expertise: reseptor tyrosine kinases, vascular signal transduction

Professor Jussi Taipale, University of Helsinki, Biomedicum Helsinki, Finland
Expertise: regulatory element prediction, high throughput analyses,

Professor Peter ten Dijke, Leiden University Medical Center, the Netherlands
Expertise: RNAi libraries, TGF-b superfamily signaling

Professor Luigi Naldini, San Raffaele Telethon Insitute for Gene Therapy, Italy
Expertise: lentiviral systems, in vivo tumor targeting

Paivi Lehtinen | alfa
Further information:
http://research.med.helsinki.fi/tumorhostgenomics/default.htm
http://www.helsinki.fi

More articles from Life Sciences:

nachricht Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>