An EU funded Specific Targeted Research Project (STREP) entitled "Tumor-Host Genomics" has been launched at the University of Helsinki, Finland. The Tumor-Host Genomics project links together the resources of five European leading-edge laboratories studying major signaling pathways in mesenchymal and hematopoietic cells, forming a concerted effort to understand tumor-host interactions, and to identify novel therapeutic targets.
The European Union will fund the project with a total of 2.7 million € during the next three years. The project is coordinated by Dr. Petri Salven from the University of Helsinki. The other participating principal investigators are Dr. Kari Alitalo and Dr. Jussi Taipale, also form the University of Helsinki, Dr. Peter ten Dijke from Leiden University Medical Center in the Netherlands, and Dr. Luigi Naldini from the San Raffaele Telethon Insitute for Gene Therapy in Italy.
In addition to oncogenic mutations that act cell-autonomously, tumor cell growth depends on interactions with its microenvironment. Tumor microenvironment consists of cells of hematopoietic and mesenchymal origin, including inflammatory cells, stem and progenitor cells, fibroblasts, endothelial cells and vascular mural cells. Tumor cell growth is known to depend on the interaction of tumor cells with such stromal cells. For example, growing tumor needs to recruit normal endothelial and vascular mural cells to form its blood vessels.
Paivi Lehtinen | alfa
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