Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breakthrough for stem cell research

23.01.2006


In an Australian-first, a UNSW researcher based at the Diabetes Transplant Unit at the Prince of Wales Hospital has produced a human embryonic stem cell (hESC) line without the use of any animal products. The breakthrough eliminates the risk of animal-to-human contamination in potential stem cell therapy treatments.



In another first, the Prince of Wales Hospital is the first public institution in the country to extract stem cells from human embryos produced using IVF in infertile couples.

"This is the first hESC line produced in Australia and only the second one in the world, which does not use animals in any way. Our line grows on human fetal fibroblast feeder layer that does not require fetal calf serum," said UNSW Senior Lecturer, Dr Kuldip Sidhu, who was the scientist responsible for the creation of the line.


"Other researchers have used animal tissue to keep the hESC alive in the petri dish or as a culture to grow it on," said Dr Sidhu. "Those animal products have the potential to transmit retroviruses in humans, which could have disastrous consequences."

Human embryonic stem cell lines are derived from specialized cells from embryos donated by infertile couples that specifically consented for their excess embryos to be used in stem cell research.

These lines could eventually lead to safer treatments for conditions such as diabetes, Parkinson’s disease, spinal cord injury and even breast cancer.

"The new line, named ’Endeavour 1’, is only the fifth human embryonic stem cell line to be produced in Australia," said UNSW Professor Bernie Tuch, Director of the DTU. "We now hope to collaborate with other researchers, using this line. We will also make it available to other researchers for their own work."

The DTU also plans to use this new line in its next hands-on training course for professionals who wish to work with human embryonic stem cells. The course, planned for April, is being conducted by the New South Wales Stem Cell Network in conjunction with the DTU.

The National Health and Medical Research Council granted a licence to IVF Australia in collaboration with the DTU at the Prince of Wales Hospital to produce six stem cell lines in November 2004. Seed funding for the project came initially from the Australian Foundation for Diabetes Research, and subsequently from Diabetes Australia.

"Couples who have completed their families often ask us to donate the excess embryos created during their past treatments to research to help others," said Emeritus Professor Doug Saunders, Chair of Research & Development Committee, IVF Australia. "We are very encouraged to see the progress of this significant research project."

About stem cell lines

A stem cell line is composed of a population of cells that can replicate themselves for long periods of time in vitro, meaning out of the body. A stem cell line is able to generate all the cells in the three basic embryonic germ layers.

There are around 240 hESC lines in the world. Four other lines have been produced in Australia.

About Kuldip Sidhu

Kuldip received his PhD from India in 1978. His initial research interest has been in assisted reproduction in various animal species including humans. Last year, Dr Sidhu produced three clonal lines from an existing hESC line by flow cytometry for the first time. While at Macquarie University (1995 to 2001), his team achieved in vitro fertilization in possums, the first for any Australian marsupial. He came to the DTU in 2002 after obtaining advanced training in hESClls in Wisconsin with Professor James Thomson who produced these cells for the first time in 1998.

Susi Hamilton | EurekAlert!
Further information:
http://www.unsw.edu.au

More articles from Life Sciences:

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

nachricht Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA examines newly formed Tropical Depression 3W in 3-D

26.04.2017 | Earth Sciences

New High-Performance Center Translational Medical Engineering

26.04.2017 | Health and Medicine

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>