Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An alternative therapy against brucellosis

18.01.2006


Concepción Lecároz, a researcher from the University of Navarra, has developed a new therapy against brucellosis. This zoonosis —a disease or infection of animals which can be transmitted to humans under natural conditions— annually affects 500,000 people worldwide. This research project forms part of her doctoral thesis, defended at the University’s School of Pharmacy.



This study has permitted the development of a new treatment which significantly reduces infections in mice, as opposed to the traditional treatment with “free” (unencapsulated) antibiotics with short treatment times. Despite the fact that brucellosis is highly susceptible to the majority of antibiotics, the indices of relapse in humans ranges from 5 to 15% depending on the antibiotic regimen; in any case, standard treatment requires combined therapy during long periods of time.

The alternative treatment developed by Ms. Lecároz involves the transportation of the antibiotic gentamicina to infected cells by means of biodegradable particles, which can produce a much higher concentration of antibiotic precisely in the organs which are infected. These biodegradable systems are designed in such a way that they release the antibiotic in a controlled manner, which allows therapeutic levels of antibiotics after a reduced number of dosages.


The next step: human trials

In this research project, Concepción Lecároz has achieved a significant reduction of spleen pathogens in mice, which has led to the possibility of achieving similar results in humans.

In Spain, along with tuberculosis and meningococcal meningitis, brucellosis is one of the most frequent endemic bacterial pathologies. The characteristic symptoms of the disease are fever, chills, weakness, muscular pain, sweating and headaches. If the bacteria invades the bloodstream, it can infect numerous tissues and organs, such as the liver, the spleen, the bones, the genitourinary system, the lungs, the central nervous system, and the heart, to the point of even endangering the life of the patient.

Irati Kortabitarte | alfa
Further information:
http://www.basqueresearch.com/berria_irakurri.asp?Gelaxka=1_1&Berri_Kod=858&hizk=I

More articles from Life Sciences:

nachricht Hunting pathogens at full force
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung

nachricht A 155 carat diamond with 92 mm diameter
22.03.2017 | Universität Augsburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>