A perfect model to study GPCR activation and dimerization
We have aspired at understanding and further dissecting the molecular mechanism of activation of the Glycoprotein hormone receptors (GpHr), members of the G protein coupled receptor (GPCR) superfamily.
First, we have focused on a network of polar interactions among highly conserved residues within the transmembrane (TM) region. Combination of site-directed mutagenesis and molecular dynamics simulations applied to the thyrotropin receptor (TSHr) have allowed identification of the residue N7.49, belonging to the canonical NPxxY motif of TM 7, as a molecular control in the mechanism of TSHr activation. N7.49 appears to adopt two different conformations in the inactive and active states. The inactive conformation is maintained by interactions with residues T6.43 and D6.44 (GpHr specific residues, located at the bottom of TM 6). Mutations that disrupt these interactions result in constitutive receptor activation. Our data suggest that upon receptor activation N7.49 undergoes a conformational change and that it might interact with D2.50 and a charged residue not identified yet. Moreover, the conserved L2.46 of the (N/S)LxxxD motif also seems to play a significant role in restraining the receptor in the inactive state.
Garazi Andonegi | alfa
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research