A perfect model to study GPCR activation and dimerization
We have aspired at understanding and further dissecting the molecular mechanism of activation of the Glycoprotein hormone receptors (GpHr), members of the G protein coupled receptor (GPCR) superfamily.
First, we have focused on a network of polar interactions among highly conserved residues within the transmembrane (TM) region. Combination of site-directed mutagenesis and molecular dynamics simulations applied to the thyrotropin receptor (TSHr) have allowed identification of the residue N7.49, belonging to the canonical NPxxY motif of TM 7, as a molecular control in the mechanism of TSHr activation. N7.49 appears to adopt two different conformations in the inactive and active states. The inactive conformation is maintained by interactions with residues T6.43 and D6.44 (GpHr specific residues, located at the bottom of TM 6). Mutations that disrupt these interactions result in constitutive receptor activation. Our data suggest that upon receptor activation N7.49 undergoes a conformational change and that it might interact with D2.50 and a charged residue not identified yet. Moreover, the conserved L2.46 of the (N/S)LxxxD motif also seems to play a significant role in restraining the receptor in the inactive state.
Garazi Andonegi | alfa
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
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At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
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