A perfect model to study GPCR activation and dimerization
We have aspired at understanding and further dissecting the molecular mechanism of activation of the Glycoprotein hormone receptors (GpHr), members of the G protein coupled receptor (GPCR) superfamily.
First, we have focused on a network of polar interactions among highly conserved residues within the transmembrane (TM) region. Combination of site-directed mutagenesis and molecular dynamics simulations applied to the thyrotropin receptor (TSHr) have allowed identification of the residue N7.49, belonging to the canonical NPxxY motif of TM 7, as a molecular control in the mechanism of TSHr activation. N7.49 appears to adopt two different conformations in the inactive and active states. The inactive conformation is maintained by interactions with residues T6.43 and D6.44 (GpHr specific residues, located at the bottom of TM 6). Mutations that disrupt these interactions result in constitutive receptor activation. Our data suggest that upon receptor activation N7.49 undergoes a conformational change and that it might interact with D2.50 and a charged residue not identified yet. Moreover, the conserved L2.46 of the (N/S)LxxxD motif also seems to play a significant role in restraining the receptor in the inactive state.
Garazi Andonegi | alfa
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02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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