Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study identifies molecule essential for proper localization of blood stem cells

16.01.2006


Result supports interaction between bone formation and production of blood, immune cells



Scientists at the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HCSI) have defined a molecule that dictates how blood stem cells travel to the bone marrow and establish blood and immune cell production. The discovery may help improve bone marrow stem cell transplantation and the treatment of several blood disorders.

"This is another remarkable example of how bone and bone marrow interact. A receptor known to participate in the body’s regulation of calcium and bone also is critical for stem cells to engraft in the bone marrow and regenerate blood and immune cells," says David Scadden, MD, director of the MGH Center for Regenerative Medicine and co-director of the HSCI. "It reminds us how tissues interact and how looking closely at where stem cells reside may tell us a lot about how to manipulate them." Scadden is senior author of the report, which will be published in the journal Nature and has received early online release.


Hematopoietic or blood stem cells are critical to the daily production of over 10 billion blood cells and are the basis for bone marrow transplant therapy for cancer. Rare and difficult to identify, these cells are extremely powerful at regenerating blood and immune cells but only if they travel to the proper location when introduced into the body. Typically the cells are infused into a vein, and they find their way to the bone marrow through a process that depends on largely unknown molecules.

Within the bone marrow cavity, stem cells are usually found in the outer layer close to the inner surface of the bone. Since the process of remodeling bone takes place in the adjacent bone tissue and because studies by Scadden’s group and others have shown that bone-forming osteoblast cells are essential to the regulation of the stem cell environment, it seemed probable that fundamental interactions exist between the processes of bone formation and stem cell development. As increased extracellular calcium is required for bone formation, the researchers theorized that a molecule called the calcium-sensing receptor (CaR), present on many cells, might be key to the localization of blood stem cells.

To test their theory, the researchers first verified the presence of CaR on primitive marrow cells taken from normal mice. They then ran several experiments using transgenic mice that do not produce the CaR protein and found that, while many types of marrow and adjacent bone cells were present in normal proportions, levels of blood stem cells were very low in the marrow cavities of the transgenic mice. Other experiments showed that the absence of other cell-surface molecules did not affect the numbers of stem cells in the marrow.

Examination of the spleens and the blood of the transgenic mice showed that the numbers of primitive blood stem cells were significantly elevated in those areas, indicating that the absence of CaR did not affect the production of stem cells by the fetal liver. In a group of normal mice that received radiation at doses that would destroy the bone marrow, transplantation of fetal liver cells from mice with and without CaR allowed the animals to survive, but those who received cells from CaR-negative mice had dramatically fewer stem cells in their bone marrow. Additional experiments showed that the CaR-negative cells were unable to adhere to collagen I, an essential bone protein produced by the osteoblasts.

"Since there are already drugs available that target this receptor, we may be able to quickly adapt these findings in animals to the treatment of human patients," says Scadden, who is a professor of Medicine at Harvard Medical School.

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu/

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

Beyond the limits of conventional electronics: stable organic molecular nanowires

24.05.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>