An approach to treating intestine cancer is being developed by Russian researchers from the Bioengineering Centre, Russian Academy of Sciences, under Anna Prokhorchuk’s guidance jointly with American colleagues sponsored by the international CRDF foundation and the Federal Agency for Science and Innovation (Rosnauka).
Any cancerous disease changes the genetic landscape – some genes are suppressed, others get activated, which results in tumour growth, the formation of metastases, and cancer spreads beyond immune system control. The universal mechanism which regulates genes’ activity is DNA methylation, where a methyl group is joined to a certain section of a molecule. Special methyl-DNA binding proteins come into action, bound with a section of the methylated DNA and this suppresses gene activity. The researchers are interested in one of such proteins named Kaiso. They assume that this protein plays an important role in the intestine cancer development, and it can be used for diagnostics and treatment.
First, the researchers measured the level of expression of the Kaiso protein gene in intestinal tumours in mice and in human patients. The level of expression turned out to be dozens of times higher than that in healthy organs and tissues. ‘Kaiso-zero’ mice were then used which were found to be resistant to cancer. The same resistance to cancer was acquired by mice whose DNA methylation had been suppressed by other methods.
Sergey Komarov | alfa
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On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
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Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
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Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
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Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
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17.10.2017 | Event News
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