Not long ago, the biochemist’s main tool was a chromatograph or an electrophoresis plant, but now specialists in bio-informatics use special software to simulate biochemical processes and the behaviour of complex molecules.
This approach was used to research factitious proteins of the cytochrome P450 family by researchers from the V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, guided by A.V. Lisitsa, Ph.D. (Biology), and their colleagues from Vanderbilt University (USA) guided by Doctor Larisa Podust. The project has been sponsored by Rosnauka and the CRDF foundation.
Proteins of this family play an important role in the organism: they are responsible for oxidation of xenobiotics – alien chemical compounds harmful to cells. Oxidation assists in removing xenobiotics from the organism, providing for cells’ purification from chemical skimming. The primary importance of cytochromes P450 resulted in the fact that these proteins are found practically in all existing organisms – in bacteria, plants, fungi and animals. Preserving general function universality, cytochromes P450 show great diversity in their structural organization.
Sergey Komarov | alfa
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
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