Not long ago, the biochemist’s main tool was a chromatograph or an electrophoresis plant, but now specialists in bio-informatics use special software to simulate biochemical processes and the behaviour of complex molecules.
This approach was used to research factitious proteins of the cytochrome P450 family by researchers from the V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, guided by A.V. Lisitsa, Ph.D. (Biology), and their colleagues from Vanderbilt University (USA) guided by Doctor Larisa Podust. The project has been sponsored by Rosnauka and the CRDF foundation.
Proteins of this family play an important role in the organism: they are responsible for oxidation of xenobiotics – alien chemical compounds harmful to cells. Oxidation assists in removing xenobiotics from the organism, providing for cells’ purification from chemical skimming. The primary importance of cytochromes P450 resulted in the fact that these proteins are found practically in all existing organisms – in bacteria, plants, fungi and animals. Preserving general function universality, cytochromes P450 show great diversity in their structural organization.
Sergey Komarov | alfa
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