An international team of researchers, led by investigators at Washington University School of Medicine in St. Louis, are zeroing in on a gene that increases risk for Alzheimers disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans.
"There are a few genes that have been implicated in the development of early-onset Alzheimers disease, but other than APOE, no genes have been found that increase risk for the more common, late-onset form of the disease," says principal investigator Alison M. Goate, D. Phil., the Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry at Washington University. "The region of DNA identified in our study showed evidence of replication in four independent series of experiments. I havent seen a putative risk factor show such consistent results since the e4 variant of the APOE gene was identified as a risk factor for late-onset Alzheimers disease more than 10 years ago."
In the January issue of the American Journal of Human Genetics, Goates team of researchers reports results of a scan of more than 1,400 single-nucleotide polymorphisms (SNPs) on chromosome 10 to home in on susceptibility genes for late-onset Alzheimers disease.
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