Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A European Centre for Structural Biology inaugurated in Grenoble

10.01.2006


On 13 January the new Carl-Ivar Brändén Building (CIBB) will be inaugurated on the Polygone Scientifique Campus in Grenoble, France. The CIBB will be operated as a collaboration between major international and national partners based in Grenoble and is a further step in the development of the region as a European centre of excellence for structural biology.


The new Carl Ivar Braendén building.



The CIBB comprises two complementary units: the Partnership for Structural Biology (PSB), whose members include the European Molecular Biology Laboratory (EMBL), the European Synchrotron Radiation Facility (ESRF), the Institut de Biologie Structurale (IBS) and the Institut Laue-Langevin (ILL), and the Institut de Virologie Moléculaire et Structurale (IVMS, associated with the Université Joseph Fourier and the CNRS).

“These partners offer an amazing range of expertise in the life sciences, and the Grenoble campus is an ideal place to cluster them together in an important new centre for structural biology”, says Eva Pebay-Peyroula, Director of the IBS and current Chair of the PSB. “It benefits from the presence of some of the world’s most important instruments for structural biology: the ESRF’s X-ray source is one of the most powerful in the world, and the ILL offers the world’s leading source of neutrons.”


For many years the ESRF, ILL and EMBL have collaborated in offering scientists services and training connected to these instruments, already making the site a pivotal contact point for large European research projects and interdisciplinary collaborations.

The CIBB will house research groups and a complete pipeline for carrying out high-throughput structural investigations of proteins and other molecules, with a particular focus on molecules related to human diseases. The facilities include laboratories for high-throughput protein purification and expression, robotic crystallisation facilities, deuteration and isotope labelling, nuclear magnetic resonance, mass-spectrometry and cryo-electron microscopy.

“By assembling all the components of this pipeline in a unique platform under one roof, we can greatly speed up the process of investigating molecules and processes relevant to diseases,” says Rob Ruigrok, Professor at the Université Joseph Fourier and Director of the IVMS.

One example of work to be carried out at the CIBB will be the molecular and cellular basis of viral diseases. Researchers plan to investigate, for example, proteins on the surfaces of viruses which allow them to dock onto receptor proteins, and then gain entry into human cells. Once inside, the virus hijacks crucial cellular processes and eventually destroys the host, following a range of molecular interactions.

Investigating the key steps in these processes should allow the identification of specific molecular reactions that may be potential drug targets. Designing efficient inhibitors will require three-dimensional structures – atom-by-atom maps of proteins and other molecules. The necessary level of resolution cannot be obtained with microscopes, so scientists turn to high-intensity X-ray beams, like those produced by the ESRF, and neutrons from the ILL. The many types of skills and expertise necessary for such analyses of molecular structures have now been brought together in the CIBB.

This strategy of combining complementary expertise already has proven itself in past collaborative projects between the institutes. For example, since the PSB was founded in 2002, scientists have obtained crucial insights into fundamental biological processes that play a role in disease, and as part of the EU SPINE (Structural Proteomics in Europe) project, the PSB has produced potential drug targets in the battle against disease-causing bacteria and viruses.

“The CIBB is a concrete manifestation of the interdisciplinary and international scientific collaboration necessary today to push forward fundamental disease research in this new era of high-throughput biology” says Stephen Cusack, Head of EMBL’s Outstation in Grenoble. “It received generous funding from the European Union’s Framework Programme”.

Montserrat Capellas | alfa
Further information:
http://www.esrf.fr/NewsAndEvents/PressReleases/CIBB

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>