Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibiotics do not prevent recurrent myocardial infarcts in subjects with periodontitis

06.01.2006


Periodontitis, an infection of the gingiva and tooth-supporting tissues, may influence the effectiveness of antibiotics used for the prevention of recurrent cardiovascular events. A three-month course of treatment with antibiotics decreased recurrence of cardiovascular events in patients without periodontitis, while the medication was found to have no effect in patients with periodontitis. This is the first time dental infections have been linked to the effectiveness of long-term treatment with antibiotics designed to prevent myocardial infarcts.



This information was the result of research partially funded by the Academy of Finland and conducted at the Institute of Dentistry, University of Helsinki, and at the Divisions of Cardiology and Infectious Diseases in the Hospital District of Helsinki and Uusimaa. The results of the research are published in the journal Atherosclerosis in January.

According to the results, long-term antibiotic medication would prevent myocardial infarcts in patients that do not have periodontitis, or related signs of inflammation such as disease-causing bacteria or antibodies to those bacteria. Periodontitis appears to be such a significant chronic infection that the effect of antibiotic treatment in preventing cardiovascular events is lost in patients that suffer from it. During one year of observation, patients with no signs of periodontitis were more likely to avoid new cardiovascular events. A total of 79% survived without a new cardiovascular event compared with 74% of patients without teeth and 66% of those with periodontitis.


The differences in patients under the age of 65 were even more noticeable: 90% of non-periodontitis subjects completed the year without a new cardiovascular event, compared with only 64% of those with periodontitis and 50% of those without teeth. In patients under the age of 65, periodontitis may cause a fivefold increase in the risk of recurrent, acute cardiovascular events in comparison with healthy people.

The research material examined 141 patients that were hospitalised for acute cardiovascular events (myocardial infarct or unstable angina pectoris). The double-blind trial involved registering the recurrence of new cardiovascular events over one year of observation following the administration of a three-month course of clarithromycin/placebo. X-rays were used to evaluate the status of teeth and tooth-supporting tissues. The presence of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, the two most important periodontal pathogens, was studied in the saliva, and the serum antibodies for these bacteria were measured using a method developed and used only at the Institute of Dentistry, University of Helsinki.

Periodontitis is an infection of the gingiva and tooth-supporting tissues that destroys the tissue fibres and alveolar bone that supports the teeth, and may eventually lead to loss of teeth. According to the Health 2000 study, up to 64% of the Finnish adult population has deepened periodontal pockets related to periodontitis and about 20% have a severe form of the disease.

Terhi Loukiainen | alfa
Further information:
http://www.aka.fi

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>