Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hodgkin lymphoma: A unique example for tumor cell reprogramming

22.12.2005


Researchers at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch (Germany) and the Charité University Medicine Berlin (Campus Virchow and Campus Buch) have discovered a molecular mechanism which explains why the cells of Hodgkin lymphoma, a malignancy affecting the lymph nodes, can change their appearance and take on characteristics of other cell lineages. "This is a perfect example of the ability of the B cells, a specific type of human immune cells affected by Hodgkin lymphoma, to be able to modify their differentiation program", say Dr. Stephan Mathas and Dr. Martin Janz from Professor Bernd Dörken’s group at the MDC and the Charité. Their findings have now been published online in advance in Nature Immunology (doi:10.1038/ni1285, 2005)*. Their data also make it clear why it has been so difficult to find out which cells in the body are affected by the disease which was first described in the literature in 1832 by the English physician and pathologist Thomas Hodgkin. Not until 1994, 160 years after he had initially described the disease, scientists had found out that it originates in the B cells, specific white blood cells of the immune system. Now, the data of the Berlin research group also help to understand the process of normal and malignant B cell development.



The various white blood cells, as well as the red blood cells and the blood platelets, develop from blood stem cells in the bone marrow, orchestrated by different molecular switches called transcription factors. They tell the cells which direction "to go". Until now, it has been assumed that once human blood cells have developed into one direction they are no longer able to leave their path. However, experiments in mice have shown that mature B cells have the ability to do exactly this: reprogramming and developing into different cell lineages. Until now, it was unclear whether human blood cells can undergo similar processes.

Now, Dr. Mathas and Dr. Janz were able to show that in Hodgkin Reed Sternberg cells, which originate from B cells, the program which steers the differentiation of B cells is defect. One of the central regulators of B cell development, called E2A, is blocked by two antagonists, known as Id2 and ABF-1. Following inhibition of E2A, B cell characteristics are lost and genes for markers of other immune cells, such as macrophages and T cells, which are not characteristic for B cells, are upregulated. Thus, the B cells have changed their appearance. These findings shed light on the extraordinary appearance of Hodgkin Reed Sternberg lymphoma cells.


* Intrinsic inhibition of E2A by ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Stephan Mathas1,2*, Martin Janz1,2*, Franziska Hummel2, Michael Hummel3, Brigitte Wollert-Wulf2, Simone Lusatis2 , Ioannis Anagnosto-poulos3, Andreas Lietz2, Mikael Sigvardsson4, Franziska Jundt1,2, Korinna Jöhrens3, Kurt Bommert2, Harald Stein3 and Bernd Dörken1,2

1Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin; 2Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Campus Berlin-Buch, Augustenburger Platz 1, 13353 Berlin; 3Institute for Pathology, Charite, Medical University Berlin, Campus Benjamin Franklin, 12200 Berlin; 4Department for Hematopoietic Stemcell Biology, Stemcell Center, Lund University, S221 84 Lund, Sweden

*These authors contributed equally to this work
Press and Public Affairs
Max Delbrück Center for Molecular Medicine(MDC) Berlin-Buch
Barbara Bachtler
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49/30/9406-38 96
Fax.: +49/30/9406-38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | idw
Further information:
http://www.mdc-berlin.de

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>