Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Hodgkin lymphoma: A unique example for tumor cell reprogramming


Researchers at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch (Germany) and the Charité University Medicine Berlin (Campus Virchow and Campus Buch) have discovered a molecular mechanism which explains why the cells of Hodgkin lymphoma, a malignancy affecting the lymph nodes, can change their appearance and take on characteristics of other cell lineages. "This is a perfect example of the ability of the B cells, a specific type of human immune cells affected by Hodgkin lymphoma, to be able to modify their differentiation program", say Dr. Stephan Mathas and Dr. Martin Janz from Professor Bernd Dörken’s group at the MDC and the Charité. Their findings have now been published online in advance in Nature Immunology (doi:10.1038/ni1285, 2005)*. Their data also make it clear why it has been so difficult to find out which cells in the body are affected by the disease which was first described in the literature in 1832 by the English physician and pathologist Thomas Hodgkin. Not until 1994, 160 years after he had initially described the disease, scientists had found out that it originates in the B cells, specific white blood cells of the immune system. Now, the data of the Berlin research group also help to understand the process of normal and malignant B cell development.

The various white blood cells, as well as the red blood cells and the blood platelets, develop from blood stem cells in the bone marrow, orchestrated by different molecular switches called transcription factors. They tell the cells which direction "to go". Until now, it has been assumed that once human blood cells have developed into one direction they are no longer able to leave their path. However, experiments in mice have shown that mature B cells have the ability to do exactly this: reprogramming and developing into different cell lineages. Until now, it was unclear whether human blood cells can undergo similar processes.

Now, Dr. Mathas and Dr. Janz were able to show that in Hodgkin Reed Sternberg cells, which originate from B cells, the program which steers the differentiation of B cells is defect. One of the central regulators of B cell development, called E2A, is blocked by two antagonists, known as Id2 and ABF-1. Following inhibition of E2A, B cell characteristics are lost and genes for markers of other immune cells, such as macrophages and T cells, which are not characteristic for B cells, are upregulated. Thus, the B cells have changed their appearance. These findings shed light on the extraordinary appearance of Hodgkin Reed Sternberg lymphoma cells.

* Intrinsic inhibition of E2A by ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Stephan Mathas1,2*, Martin Janz1,2*, Franziska Hummel2, Michael Hummel3, Brigitte Wollert-Wulf2, Simone Lusatis2 , Ioannis Anagnosto-poulos3, Andreas Lietz2, Mikael Sigvardsson4, Franziska Jundt1,2, Korinna Jöhrens3, Kurt Bommert2, Harald Stein3 and Bernd Dörken1,2

1Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin; 2Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Campus Berlin-Buch, Augustenburger Platz 1, 13353 Berlin; 3Institute for Pathology, Charite, Medical University Berlin, Campus Benjamin Franklin, 12200 Berlin; 4Department for Hematopoietic Stemcell Biology, Stemcell Center, Lund University, S221 84 Lund, Sweden

*These authors contributed equally to this work
Press and Public Affairs
Max Delbrück Center for Molecular Medicine(MDC) Berlin-Buch
Barbara Bachtler
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49/30/9406-38 96
Fax.: +49/30/9406-38 33

Barbara Bachtler | idw
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Novel mechanisms of action discovered for the skin cancer medication Imiquimod

21.10.2016 | Life Sciences

Second research flight into zero gravity

21.10.2016 | Life Sciences

How Does Friendly Fire Happen in the Pancreas?

21.10.2016 | Life Sciences

More VideoLinks >>>