Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists close in on genes responsible for Parkinson’s disease

21.12.2005


Scientists have identified 570 genes that act abnormally during the development of Parkinson’s Disease, a finding which could help doctors predict the likelihood of it developing, and provide targets for new treatments.



The research published in Neurogenetics, by the team from Imperial College London and the University of Liege, Belgium, uses microarrays to analyse brains from Parkinson’s patients. Microarrays are laboratory chips able to pick out which genes are active when different processes are occurring in the brain. When they analysed brains from people with Parkinson’s, they found that out of all 25,000 human genes, regulation of 570 was highly abnormal in Parkinson’s brains compared with non-diseased brains. This is the first study on Parkinson’s disease where all human genes were studied.

The researchers analysed 23 brains from recently deceased patients, 15 affected by Parkinson’s and 8 control brains. The majority of brains were provided by the UK Parkinson’s Disease Society Tissue Bank at Imperial College London.


Dr Linda Moran from Imperial College London and one of the authors of the paper, said: "This research shows there are a considerable number of genes associated with the development of Parkinson’s, potentially providing new clues for how to treat this disease. Now that we can identify these genes it may be possible to develop new therapies to help the increasing numbers of Parkinson’s patients."

The team, led by Professor Manuel Graeber, analysed two parts of the brain which are affected by neurodegeneration in Parkinson’s; the substantia nigra in the mid-brain, and the cerebral cortex. They were able to eliminate around 15,000 genes from any role in Parkinson’s, as they were not found to be active in the substantia nigra, the part of the brain most affected by Parkinson’s.

Dawn Duke, MS, from Imperial College London, and one of the authors of the paper said: "In addition to identifying those genes linked with the development of Parkinson’s, this research has also shown that many of these genes were especially active in Parkinson’s brains. By limiting the activity of these genes, we may be able to control or even stop the development of Parkinson’s."

Tony Stephenson | EurekAlert!
Further information:
http://www.imperial.ac.uk

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>