Blood taken from a normal mouse The blue coloring is characteristic of blood cells called blasts, which are proliferating. Blasts are in a small minority. © F. Moreau-Gachelin/Institut Curie
Blood taken from a leukemic mouse In blood taken from a leukemic mouse, the proliferating cells are much more numerous, indicating the presence of leukemic cells. © F. Moreau-Gachelin/Institut Curie
At the Institut Curie, an Inserm team has just identified the molecular mechanism long suspected to account for the formation of malignant cells in the most frequent leukemia – acute myeloid leukemia. For a cell to become leukemic, it must not only proliferate but also no longer become specialized. Mutations in its gene confer autonomous activity on the Kit receptor, thereby allowing cells to proliferate in the absence any external signal.This study was published in the 12 December 2005 issue of Cancer Cell.
Blood cells are produced in the bone marrow from stem cells. In response to growth factors, stem cells differentiate into precursor cells of three blood lines: red blood cells (also called erythrocytes), white blood cells (lymphocytes, macrophages…) and platelets. The cells are only released into the blood when they reach maturity.
Leukemias are malignant blood diseases characterized by the uncontrolled proliferation of blood cells. Lymphoid leukemias, which affect lymphocytes, are distinct from myeloid leukemias, which affect the precursors of all the other blood cell lines. The acute nature of leukemia is reflected in a complete absence of mature cells and in the presence in the bone marrow of numerous cells blocked at an early stage of their maturation.
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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