Blood taken from a normal mouse The blue coloring is characteristic of blood cells called blasts, which are proliferating. Blasts are in a small minority. © F. Moreau-Gachelin/Institut Curie
Blood taken from a leukemic mouse In blood taken from a leukemic mouse, the proliferating cells are much more numerous, indicating the presence of leukemic cells. © F. Moreau-Gachelin/Institut Curie
At the Institut Curie, an Inserm team has just identified the molecular mechanism long suspected to account for the formation of malignant cells in the most frequent leukemia – acute myeloid leukemia. For a cell to become leukemic, it must not only proliferate but also no longer become specialized. Mutations in its gene confer autonomous activity on the Kit receptor, thereby allowing cells to proliferate in the absence any external signal.This study was published in the 12 December 2005 issue of Cancer Cell.
Blood cells are produced in the bone marrow from stem cells. In response to growth factors, stem cells differentiate into precursor cells of three blood lines: red blood cells (also called erythrocytes), white blood cells (lymphocytes, macrophages…) and platelets. The cells are only released into the blood when they reach maturity.
Leukemias are malignant blood diseases characterized by the uncontrolled proliferation of blood cells. Lymphoid leukemias, which affect lymphocytes, are distinct from myeloid leukemias, which affect the precursors of all the other blood cell lines. The acute nature of leukemia is reflected in a complete absence of mature cells and in the presence in the bone marrow of numerous cells blocked at an early stage of their maturation.
Researchers invent tiny, light-powered wires to modulate brain's electrical signals
21.02.2018 | University of Chicago
The “Holy Grail” of peptide chemistry: Making peptide active agents available orally
21.02.2018 | Technische Universität München
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
21.02.2018 | Life Sciences
21.02.2018 | Life Sciences
21.02.2018 | Materials Sciences