New research by a team of scientists in France and the United States has identified both the bacterial and host receptor proteins that enable Rickettsia conorii, the Mediterranean spotted fever pathogen to enter cells. Understanding how this bacterium interacts with the cells of its host could lead to new therapeutic strategies for diseases caused by related pathogens, including Rocky Mountain spotted fever and typhus.
Pascale Cossart, an HHMI international research scholar at the Pasteur Institute in Paris, together with her postdoctoral fellow Juan Martinez and collaborators in Paris and at Case Western Reserve University in Cleveland, Ohio, has identified the first receptor for a Rickettsial bacterium. Their findings will be reported in the December 16, 2005, issue of the journal Cell.
Rickettsial bacteria are transmitted by fleas, ticks, and lice to humans and other mammals, where they can cause dangerous and sometimes fatal infections. There are two types of Rickettsial pathogens—the spotted fever group, which includes the Rickettsia conorii bacteria studied by Cossart and her colleagues, and the typhus group. Both must live inside cells to survive. Rickettsia have been classified by the National Institute of Allergy and Infectious Diseases (NIAID) as agents with potential for use as tools for bioterrorism.
Jennifer Donovan | EurekAlert!
Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel
The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering