The circulation of cancer cells through the blood vessels is often the cause of metastasis. These cancer cells contaminate normal cells and the pathology spreads throughout the body. Metastasis is the main risk in cancers. In order to prevent this process from occurring, a team from the Chemistry Faculty at the Donostia-San Sebastián campus of the University of the Basque Country (UPV-EHU) analysed the connections between cancer and normal cells.
Concretely, the UPV-EHU analysed the proteins that are involved in these connections. From amongst these proteins, they chose the ones that have a single active centre. If this centre is blocked, the cancer cell will not be able to adhere itself to a healthy cell and, thus, this path of spreading the disease is blocked.
The first thing to do is to analyse the structure of the proteins chosen. This task is undertaken using computers, given that the proteins are gigantic molecules. Once the structure is analysed and with the data for the active centre of the connection, the design of a new, small molecule to block this centre is initiated.
Garazi Andonegi | alfa
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