Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A crucial role for TGFbeta signaling in congenital eye disorders

14.12.2005


The lens in the developing eye acts as a TGFbeta signaling center that controls differentiation, survival and formation of multiple eye structures deriving from the neural crest. A study published today in the open access journal Journal of Biology shows that neural crest (NC) derived cells contribute to both anterior and posterior parts of the developing mammalian eye. NC cells migrate properly in the eye but fail to differentiate in the absence of TGFbeta signaling. The activity of TGFbeta is mediated by the two transcription factors Foxc1 and Pitx2 that have been implicated in human eye disorders. These findings shed light on the origin of congenital eye disorders that can give rise to glaucoma and blindness: Axenfeld-Rieger’s anomaly and persistent hyperplastic primary vitreous.



Lukas Sommer, from the Institute of Cell Biology at the ETH in Zurich, Switzerland, heading an international team including Lars Ittner, used in vivo cell fate mapping in mice. They show that NC-derived cells can be found in the eye vesicle of mouse embryos, soon after it is formed. NC-derived cells subsequently contribute to various structures of the developing eye, and Ittner et al. show for the first time an NC contribution to the primary vitreous.

TGFbeta receptor type 2, Tgfbr2, was inactivated to study the importance of the signaling pathway in NC-derived cells. In these mice, the eyes were reduced in size and the lens and cornea failed to separate. The authors show that TGFbeta signaling is crucial for proper differentiation and morphogenesis of NC-derived cells in eye structures. Conceivably, TGFbeta might be able to support differentiation not only during eye development but also at later stages. If so, this might open up new strategies for promoting regeneration of eye structures, for example in patients suffering from loss of corneal transparency.

Grace Baynes | EurekAlert!
Further information:
http://www.biomedcentral.com

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>