Friedman School of Tufts: Nutrition notes
Two obese people follow the same low-calorie diet and do not exercise, but one loses much more weight than the other. Genetic factors may explain this phenomenon, according to José Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University. In a study published in the Journal of Clinical Endocrinology & Metabolism, Ordovas and colleagues identified a variation in the perilipin gene that appears to render some people resistant to weight loss from calorie restriction. This research builds on their earlier work on perilipin and obesity.
"It is as if the connection between calorie intake and body weight is interrupted," explains Ordovas, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts. "Carriers of this gene variant appear to have more stable mechanisms for controlling their body weight," Ordovas says. "In people that have become obese, this leads to a blunting of the weight-loss effect we would expect to see with calorie restriction."
Siobhan Gallagher | EurekAlert!
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