In the December 15th issue of G&D, Dr, Michael Snyder and colleagues (Yale University) explore transcription factor binding under different cell activation conditions.
The authors used a ChIP-chip approach to map out STAT1 and STAT2 binding sites along the human chromosome 22 after IFN-alpha or IFN-gamma stimulation. They found that STAT1 displays stimulus-dependent binding activity:
While 52 binding sites are conserved between IFN-alpha and IFN-gamma treatment, 100 targets are exclusive to IFN-gamma stimulation. Additional insight into the regulation of gene expression by STAT proteins is particularly important given the widespread clinical usage of interferon treatments in human disease.
Heather Cosel | EurekAlert!
Two Group A Streptococcus genes linked to 'flesh-eating' bacterial infections
25.09.2017 | University of Maryland
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
A warming planet
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
25.09.2017 | Power and Electrical Engineering
25.09.2017 | Health and Medicine
25.09.2017 | Physics and Astronomy