Researchers identify key gene sequences that promote growth of new arteries when existing arteries are blocked
Researchers at the San Francisco VA Medical Center have uncovered part of the genetic mechanism that causes new arteries to grow in response to blocked arteries. A team led by SFVAMC vascular surgeon Rajabrata Sarkar, MD, PhD, has demonstrated in mice that the MMP2 gene is essential for the growth of new arteries when the femoral (leg) artery is blocked.
The team also identified and described, for the first time, the specific DNA sequences of the MMP2 gene that are expressed when new arteries are grown. The study appears in the November 8 issue of the Proceedings of the National Academy of Sciences. "It is not clear why some patients grow new arteries in response to an arterial blockage and others do not," observes Sarkar, who is also an assistant professor of surgery at the University of California, San Francisco. "So it’s very important to understand the normal process that allows an animal or a person to grow new arteries when their legs don’t get good blood flow. Legs are a big problem, because if you don’t have enough blood flow, it can eventually lead to gangrene and amputation."
Steve Tokar | EurekAlert!
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