p53 and organogenesis

A paper published in the December 1st issue of Genes & Development reveals a novel role for the p53 tumor suppressor pathway in organogenesis during embryonic development. Dr. Jinrong Peng and colleagues show that the zebrafish Def protein is an organ-specific factor that represses expression of a newly identified p53 isoform to coordinate digestive organ growth. def-mutant zebrafish display hypomorphic digestive organs that result from defects in organ expansion and maturation.

Further analysis demonstrated that the increased expression of the delta113 p53 isoform in def-mutant digestive organs leads to cell cycle arrest and reduced organ growth.

Dr. Peng explains that “based on all data obtained in our hands thus far, we believe the increase in p53 ispform in the def mutant contributes significantly (but not fully) to cause the hypoplasia digestive organs.

Media Contact

Heather Cosel EurekAlert!

More Information:

http://www.cshl.edu

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Properties of new materials for microchips

… can now be measured well. Reseachers of Delft University of Technology demonstrated measuring performance properties of ultrathin silicon membranes. Making ever smaller and more powerful chips requires new ultrathin…

Floating solar’s potential

… to support sustainable development by addressing climate, water, and energy goals holistically. A new study published this week in Nature Energy raises the potential for floating solar photovoltaics (FPV)…

Skyrmions move at record speeds

… a step towards the computing of the future. An international research team led by scientists from the CNRS1 has discovered that the magnetic nanobubbles2 known as skyrmions can be…

Partners & Sponsors