Mitosis in human embryonic stem (hES) cell cytoplast cybrid following fusion. A, B, C, D: Increasing appearance in background of red fluorescence [octamer binding transcription factor-4 (Oct-4)] surrounded by ring of green fluorescence [tumour rejection antigen-2-39 (TRA-2-39)], with no nucleoli being present. Blue fluorescence: DAPI, showing the chromosome location. Original magnification x40.
Immune rejection problems could affect any one of us. This unique research shows that producing individual patient cell lines for our own future needs is now something we might all want to consider.
Somatic cell nuclear transfer (SCNT) forms the basis for obtaining patient specific stem cells and with the presence of reprogramming factors in human embryonic stem (hES) cells, a method for replacing the nuclei of hES cells by somatic cell nuclei has been widely sought.
Nick Strelchenko et al. based at the Reproductive Genetics Institute in Chicago, USA, has now developed an original technique resulting in the first evidence of the complete replacement of the nuclei of hES cells by nuclei of somatic cells. Their paper Reprogramming of human somatic cells by embryonic stem cell cytoplast is accepted and was published online by Reproductive BioMedicine Online, www.rbmonline.com/Article/2071 on 18 November 2005. The final article will also be published in print in the January 2006 issue of the journal.
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy