Saint Louis University influenza researcher comments in Nov. 24 issue
An article by Robert Belshe, M.D., of Saint Louis University School of Medicine in this weeks New England Journal of Medicine reviews recent "spectacular achievements of contemporary molecular biology" that hold great importance as the world prepares for a possible flu pandemic.
These achievements, including a recent genetic sequencing and recreation of the virus from the 1918 flu pandemic, "may enable us to track viruses years before they develop the capacity to replicate with high efficiency in humans," Belshe writes.
Belshe said the question of the moment involves which mechanism a future pandemic could involve. "Are we going to see an event like 1918, an avian virus adapting to man, or will it be an event like 1957 or 1968, where an avian virus contributes some genetic material by mixing in with a current strain of the human virus?" Belshe says. "We dont know what will happen or when it will happen, but we know it will happen."
And although it cant be said for sure whether the current avian flu virus can adapt readily to the point where human-to-human transmission is possible, the recent research findings do provide some clues as to what genetic changes are necessary for such an event to occur. In fact, several additional genetic changes must occur in the currently circulating bird flu viruses before these viruses will begin to spread efficiently from person to person and this can be monitored closely by scientists.
"Taubenberger estimated that based upon the rate of evolution, the 1918 epidemic had circulated in man since 1900," Belshe says. "So it took a while to become highly efficient as a pandemic virus."
A copy of the full article can be found in the Nov. 24 issue of the New England Journal of Medicine (2209-2211).
Belshe is director of the Center for Vaccine Development at Saint Louis University School of Medicine. He has conducted research related to influenza for more than two decades, and he has previously published articles in the New England Journal of Medicine on the influenza anti-viral Tamiflu, on the nasal spray influenza vaccine FluMist, and last fall on intradermal administration of flu vaccinations. He has authored dozens of papers on influenza that have been covered in various scholarly journals, including a 1998 commentary in The Lancet article that warned of a coming global flu pandemic and of the necessity of preparing for one.
Joe Muehlenkamp | EurekAlert!
Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology
Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences