Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a series of transgenic mouse models of multiple system atrophy, a progressive, fatal neurological disorder. The work is reported in the November 16 issue of the Journal of Neuroscience by Eliezer Masliah, M.D., Professor of Neuroscience and Pathology at UCSD and Cliff Shults, M.D. Professor of Neuroscience at UCSD and Neurologist at the VA San Diego Healthcare System.
The mouse models are important, not only in providing new insights into the processes that cause degeneration of the nervous system in patients with multiple system atrophy, but also as models in which to study treatments for the disease.
"The models will help researchers develop therapies for this degenerative disease by enabling us to study potential treatments that might interfere with the aggregation of alpha-synuclein and slow the progression of multiple system atrophy," said Shults.
Debra Kain | EurekAlert!
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