Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New drugs in the pipeline for public health diseases


Swedish chemists synthesizing substances for blood clots, malaria, and hepatitis C.

Chemists at Linköping University in Sweden have developed three types of molecules, protease inhibitors, that can be further developed into drugs for cardiovascular diseases, malaria, and hepatitis C.

Proteases are a group of enzymes that play a major role in the course of certain diseases. If there is a molecule present that prevents the protease from working, the disease can be cured. Such substances are called inhibitors and are already in use in many drugs today.

Per-Ola Johansson, a doctoral candidate in organic chemistry, describes in his dissertation the synthesis of such protease inhibitors, designed for potential use in combating three different diseases: cardiovascular diseases (to prevent the formation of blood clots), malaria, and chronic jaundice of the type hepatitis C.

Thrombin is a protease that plays a key role when blood coagulates. In some individuals this process is hyperactive, which can lead to the formation of blood clots. The research team at Linköping University has synthesized a series of molecules that inhibit the activity of thrombin in varying degrees. The most active of these molecules give an indication of how to go about creating the optimal thrombin inhibitor to develop a functioning drug.

Malaria, which affects some 500 million people annually, killing nearly 2 million of them, is caused by a single-cell parasite that breaks down the hemoglobin in red blood corpuscles. For tools, the parasite makes use of a number of different protease enzymes. The research team has developed a large number of molecules that inhibit the activity of two of these, plasmepsin I and II. Some of these inhibitors have proven to be extremely effective and could be optimized to become a powerful new malaria drug.

Hepatitis C is caused by the virus HCV. When it proliferates, HCV forms a chain-shaped molecule that is cut in smaller pieces by various protease enzymes, and these pieces then build up new virus particles. The team has synthesized a series of inhibitors of NS3, one of the most important of these enzymes.

This work has been carried out under the supervision of Professor Ingemar Kvarnström, Professor Bertil Samuelsson, and Åsa Rosenquist, Ph.D., and in collaboration with the pharmaceutical companies Medivir and Astra Zeneca.

The dissertation is titled Design and synthesis of inhibitors that target the serine protease thrombin, the malarial aspartyl proteases plasmepsin I and II, and the hepatitis C virus NS3 serine protease.

Åke Hjelm | alfa
Further information:

More articles from Life Sciences:

nachricht Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute

nachricht 'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

How nanoscience will improve our health and lives in the coming years

27.10.2016 | Materials Sciences

OU-led team discovers rare, newborn tri-star system using ALMA

27.10.2016 | Physics and Astronomy

'Neighbor maps' reveal the genome's 3-D shape

27.10.2016 | Life Sciences

More VideoLinks >>>