A diagnostic approach will allow to quickly and precisely identify the enemy - tuberculosis culture pathogene, the approach being based on the so-called subtraction hybridization. How it can help to identify ‘personality’ of a dangerous bacterium was discussed by researchers from Moscow with their colleagues at the II International Conference “Molecular Medicine and Biosafety” in late October this year.
For smatterers the notion of tuberculosis – is necessary and sufficient for definition of the disease and its pathogene, tubercle bacillus or, in other words, Koch’s bacillus, and has long ago lost romantic veil of Chekhov’s and Dostoyevsky’s hectic heroines. However, specialists know well that considerable genetic variability is typical of the Mycobacterium tuberculosis bacteria population. Simply speaking, these pathogenes may be very different. On the one hand, according to the force of influence on human beings: some pathogens are more, figuratively speaking, ‘wicked’ (virulent), others – are less wicked. It is necessary to know where the difference lies – what changes in the microorganism’s genome cause changes in its properties, including changes in its virulence.
Furthermore, tuberculosis pathogens, like cockroaches, are able to adapt themselves to the circumstances. If they are exterminated by people, part of them dies, but the remaining ones produce posterity resistant to the applied poison. In case of tuberculosis, this is becomes apparent in occurrence of cultures resistant to this or that kind of drugs. Therefore, to treat for sure physicians use several drug substances at once – they fight, so to say, through extended front. On top of the fact that the patient gets high doses of ‘redundant’ drugs, which are far from innocuous for a patient, as a result of such mass attack there appear cultures with multiple drug resistance, and this is a real headache for those who is trying to cure the disease.
Sergey Komarov | alfa
Cnidarians remotely control bacteria
21.09.2017 | Christian-Albrechts-Universität zu Kiel
Immune cells may heal bleeding brain after strokes
21.09.2017 | NIH/National Institute of Neurological Disorders and Stroke
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
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21.09.2017 | Health and Medicine