A diagnostic approach will allow to quickly and precisely identify the enemy - tuberculosis culture pathogene, the approach being based on the so-called subtraction hybridization. How it can help to identify ‘personality’ of a dangerous bacterium was discussed by researchers from Moscow with their colleagues at the II International Conference “Molecular Medicine and Biosafety” in late October this year.
For smatterers the notion of tuberculosis – is necessary and sufficient for definition of the disease and its pathogene, tubercle bacillus or, in other words, Koch’s bacillus, and has long ago lost romantic veil of Chekhov’s and Dostoyevsky’s hectic heroines. However, specialists know well that considerable genetic variability is typical of the Mycobacterium tuberculosis bacteria population. Simply speaking, these pathogenes may be very different. On the one hand, according to the force of influence on human beings: some pathogens are more, figuratively speaking, ‘wicked’ (virulent), others – are less wicked. It is necessary to know where the difference lies – what changes in the microorganism’s genome cause changes in its properties, including changes in its virulence.
Furthermore, tuberculosis pathogens, like cockroaches, are able to adapt themselves to the circumstances. If they are exterminated by people, part of them dies, but the remaining ones produce posterity resistant to the applied poison. In case of tuberculosis, this is becomes apparent in occurrence of cultures resistant to this or that kind of drugs. Therefore, to treat for sure physicians use several drug substances at once – they fight, so to say, through extended front. On top of the fact that the patient gets high doses of ‘redundant’ drugs, which are far from innocuous for a patient, as a result of such mass attack there appear cultures with multiple drug resistance, and this is a real headache for those who is trying to cure the disease.
Sergey Komarov | alfa
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
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Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
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16.01.2017 | Power and Electrical Engineering
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16.01.2017 | Power and Electrical Engineering