A diagnostic approach will allow to quickly and precisely identify the enemy - tuberculosis culture pathogene, the approach being based on the so-called subtraction hybridization. How it can help to identify ‘personality’ of a dangerous bacterium was discussed by researchers from Moscow with their colleagues at the II International Conference “Molecular Medicine and Biosafety” in late October this year.
For smatterers the notion of tuberculosis – is necessary and sufficient for definition of the disease and its pathogene, tubercle bacillus or, in other words, Koch’s bacillus, and has long ago lost romantic veil of Chekhov’s and Dostoyevsky’s hectic heroines. However, specialists know well that considerable genetic variability is typical of the Mycobacterium tuberculosis bacteria population. Simply speaking, these pathogenes may be very different. On the one hand, according to the force of influence on human beings: some pathogens are more, figuratively speaking, ‘wicked’ (virulent), others – are less wicked. It is necessary to know where the difference lies – what changes in the microorganism’s genome cause changes in its properties, including changes in its virulence.
Furthermore, tuberculosis pathogens, like cockroaches, are able to adapt themselves to the circumstances. If they are exterminated by people, part of them dies, but the remaining ones produce posterity resistant to the applied poison. In case of tuberculosis, this is becomes apparent in occurrence of cultures resistant to this or that kind of drugs. Therefore, to treat for sure physicians use several drug substances at once – they fight, so to say, through extended front. On top of the fact that the patient gets high doses of ‘redundant’ drugs, which are far from innocuous for a patient, as a result of such mass attack there appear cultures with multiple drug resistance, and this is a real headache for those who is trying to cure the disease.
Sergey Komarov | alfa
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences