Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists identify molecular link between body fat and blood lipids

11.11.2005


Scientists from Wageningen University in the Netherlands have discovered that a factor released from body fat, which they call Fasting-Induced Adipose Factor or FIAF, has a major impact on blood levels of HDL and triglycerides in mice. The factor might be a promising drug candidate, team leader dr. Sander Kersten says. “Our study demonstrates that small changes in the production of FIAF in mice elevate blood HDL and triglycerides.”



Obesity is known to negatively influence the level of cholesterol and other fats in our blood, often causing a condition called dyslipidemia. For many years, researchers have suspected that factors secreted from body fat affect blood lipids, yet promising candidates are hard to find. Kersten explains: “We know that elevated blood levels of HDL are protective against cardiovascular disease, whereas elevated triglycerides are considered harmful. Obese people often have low HDL levels and elevated levels of triglycerides, and are therefore at increased risk for cardiovascular disease.”

“For years we have known that diet has an influence on blood lipids but improvements achieved by dietary changes alone are often unsatisfactory. While statins are very effective in reducing blood LDL levels, they hardly touch HDL and triglycerides. Therefore, there is a need for drugs that specifically address HDL and/or triglycerides. A promising drug candidate may be FIAF.” says Kersten.


The paper, which was published online on November 4 in the Journal of Biological Chemistry, shows that transgenic mice that produce more FIAF have elevated blood HDL and triglyceride levels. According to the paper, FIAF raises triglyceride levels by blocking the removal of triglycerides from blood.

What is remarkable is that FIAF binds to HDL and LDL particles. Many proteins are attached to lipoproteins circulating in blood but almost all of them are produced in liver. It is very unusual to find a protein produced in fat tissue being bound to lipoproteins.

According to Kersten, the binding to lipoproteins also shows a clear difference between mouse and human. “In mice FIAF appears to be bound to both LDL and HDL, but in humans it is only bound to HDL. It is not clear what the implications are of this variation but FIAF might very well act differently in humans than in mice.”

One possibility is that in humans FIAF mainly affects HDL levels and hardly influences triglycerides. Such an effect would be protective against cardiovascular disease.

Whether FIAF is effective towards HDL or triglycerides in humans will ultimately determine its potential as a drug target. “Right now, it is too early to tell. Hopefully, in the next few years we will get better insight into what FIAF actually does in humans”, says Kersten.

Jac Niessen | EurekAlert!
Further information:
http://www.wur.nl
http://www.wau.nl/pers/05/089wue.html

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
21.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
21.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>