Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oxygen and development - stem cell researchers notch up new insight

04.11.2005


EuroStemCell researchers at Stockholm’s Karolinska Institute have made an important new discovery about the role of oxygen in development. Their research, published this week in Developmental Cell, may shed light on the processes at work in tumour development and has implications for successfully growing stem cells in the laboratory.



Scientists have observed that stem cells grow more easily as undifferentiated cells when oxygen levels are reduced. But until this week, they didn’t know why.

The Karolinska researchers provide, for the first time, a molecular basis for this phenomenon, and uncover a role for the Notch signalling pathway in the process.


The Notch family of proteins are critical regulators in the process of differentiation – where stem cells take on more specialised functions.

“Understanding how the body precisely controls stem cell fate is a key goal of stem cell research,” says EuroStemCell researcher Urban Lendahl.

“Our finding that Notch signalling mediates the effect of reduced oxygen levels on brain and muscle stem cells will help researchers working on these cells to replicate the body’s mechanisms in the lab. This is an important prerequisite for developing safe and effective clinical applications,” Lendahl adds.

The link between Notch and reduced oxygen levels may also prove useful in cancer research. Certain types of tumour develop because of mutations in the machinery that sense reduced levels of oxygen (hypoxia) in the body. This week’s findings may provide new insights into the molecular processes at work as these tumours develop, and open up possibilities for interrupting these processes.

Dr Urban Lendahl | alfa
Further information:
http://eurostemcell.org/AboutUs/about_press.htm

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>