Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MBL study shows how good cholesterol (HDLs) provide human immunity to certain parasites

31.10.2005


For years biomedical researchers have known that high density lipoproteins, commonly called HDLs or "good cholesterol," are responsible for protecting humans from certain parasites, but couldn’t explain how. Now MBL scientists have discovered that human HDLs work this bug-repelling magic by serving as a platform for the assembly and delivery of two naturally occurring proteins that combine to create a super-toxic antimicrobial.



The research, published in the September 30 issue of the Journal of Biological Chemistry, focuses specifically on human innate immunity to Trypanosoma brucei brucei, the parasite that gives African cattle the deadly disease called Nagana, but which doesn’t harm humans even though scientists believe they are exposed to it. The parasite is a close relative of Trypanosoma brucei gambienese and Trypanosoma brucei rhodesiense, the organisms that cause African sleeping sickness in humans.

The findings that two proteins work synergistically to kill the Nagana parasite in humans contradict a long-held hypothesis that a single protein was the key to HDL’s parasite-fighting power. "The research may be helpful to veterinarians hoping to develop treatments to aid African cattle farmers, who lose three million cattle and around a billion US dollars annually to Nagana," says April Shiflett, a scientist in the MBL’s Global Infectious Diseases Program and an author on the paper. Scientists also hope the research will provide key information to investigators seeking treatments for certain parasitic infections, such as malaria.


To identify the proteins--known as apolipoprotein L-1 (apo L-1) and haptoglobin-related protein (Hpr)--MBL scientists tested different amounts and combinations of the proteins on Trypanosoma brucei brucei specimens. To survive the parasite needs to digest the lipids in HDLs. Because HDL carries these proteins and enables them to combine, it is nature’s perfect delivery system for the antimicrobial. And when test organisms digested the super-toxic protein mix, the single-celled organisms literally dissolved.

Shiflett and her colleagues in the MBL’s Global Infectious Diseases Program are focused on understanding the molecular workings of a variety of parasites, including those that cause human African sleeping sickness, Nagana, and malaria. Such research is crucial to finding creating better treatments, and possibly cures, for diseases that are ravaging the people and economies of places like Africa and other developing countries.

Funding for this study was provided by the National Institutes of Health. The complete paper can be found in the Journal of Biological Chemistry, Volume 280, Number 38.

Gina Hebert | EurekAlert!
Further information:
http://www.mbl.edu

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>