Faster Computation of Haplotypes Provides Insight into Genetic Basis of Human Disease
High-throughput sequencing of an individuals DNA yields a map of genetic variation which can give clues to the genetic underpinning of human disease. The current technologies collect genotypes, or information from the individuals two chromosomes. Yet many scientists believe that drilling down to the variations between individuals DNA at the level of each chromosome -- so-called haplotypes -- will permit more accurate study of genetic differences and their consequences for medical research and the study of evolution.
Experimental methods for deriving these haplotypes are expensive and time-consuming. But now experts in bioinformatics at two California research institutes have used a different, very fast and relatively low-cost computational tool to crunch the worlds largest repository of genotypes to predict their haplotypes -- and they did so in less than 24 hours, approximately 1,000 times faster than the prevailing technology until now. Their findings are featured in a special issue of the journal Genome Research, published today.
Doug Ramsey | EurekAlert!
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