Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lack of Gene Expression Associated with Ovarian Cancer

25.10.2005


The expression of two specific genes is almost completely downregulated in ovarian cancer tumours. An extensive analysis of gene expression in ovarian cancer tumour cells has revealed this important finding, which should be an aid to early diagnosis. The insights gained by the research at the Medical University of Vienna with the support of the Austrian Science Fund FWF are also central to a recently launched EU project aimed at optimising ovarian cancer diagnosis.



Some 63,000 cases of ovarian cancer are diagnosed in Europe every year. The symptoms of the disease seldom appear until it has reached an advanced stage, by which time it is often too late for effective treatment. Delayed diagnosis causes over 30,000 deaths.

In the Genes


A team led by Prof. Michael Krainer of the Clinic for Internal Medicine I at the Medical University of Vienna that has been looking for an early diagnosis method has now made a major breakthrough. Comparison of normal ovarian cells with advanced ovarian cancer cells highlighted molecular genetic differences. The genes identified as N33 and EFA6R are in some cases almost completely inactivated in the cancer cells. Commenting on the usefulness of the discovery in the diagnosis of cancer, Prof. Krainer noted: "At present it looks as though these two genes have already lost their activity before the appearance of clinical symptoms. We presume that this happens because methyl groups are attached to the gene’s building blocks. This is a common means of regulating gene activity. Methylation like this is easy to detect and could be an early warning sign for a developing cancer."

The expression of several genes on a particular band of the human chromosome 8 in tumour cells from over 90 patients were measured during the FWF project. In ovarian cancer there is often a loss of this chromosomal band. Earlier work in this area by Prof. Krainer’s team had already identified 22 genes. The current project has now been able to demonstrate that a total of five of these genes show very low expression levels in tumour cells. N33 and EFA6R stood out, as the reduction in their expression was associated with the progression of the disease. However, as yet the function of the genes can only be speculated on. N33 may be involved in the regulation of cell death and EFA6R in signal transmission.

Coming to your Screens

Together with Prof. Robert Zeillinger’s group at the Gynaecology and Obstetrics Clinic, Prof. Krainer has succeeded in establishing a core research focus on molecular cancer diagnostics that has gained an international reputation. Only a short time ago the Austrian scientists succeeded in identifying a receptor molecule, the absence of which promotes the development of ovarian cancer, and now they are also coordinating groups in six countries in an EU project that has just been approved. The aim of the EUR 4 million project is to identify molecular markers that would permit early diagnosis of ovarian cancer.

Highlighting the advances being made in cancer diagnosis, Prof. Krainer said: "The next step in early detection is the diagnosis of molecular genetic markers such as methylations, as they provide information on the actual development of cancer in individual patients. This means that analysis of molecular genetic markers is an ideal match for diagnosis of genetic predisposition to breast and colon cancers, for example." The diagnosis of genetic predispositions offers vital information on the likelihood that a person will have a hereditary disposition for these types of cancer. Today these genetic diagnostics already offer opportunities for adjusting expensive screening tests to individual risk profiles. This saves lifes and money - the reason why Dutch health insurance funds are prepared to pay for genetic diagnosis.

Till C. Jelitto | alfa
Further information:
http://www.fwf.ac.at/en/press/ovarian_cancer.html

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>