Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic Cancer Center finds possible genetic link to pancreatic cancer

21.10.2005


Study shows cystic fibrosis gene mutation a risk factor for young-onset disease



Mayo Clinic researchers have found the risk of developing pancreatic cancer at a young age (under 60) to be twice as high for people who carry a mutation of the gene that causes cystic fibrosis, compared to noncarriers. Results of a pilot and follow-up study were reported Oct. 14, 2005, online in the journal Gut.

Pancreatic cancer kills over 32,000 people in the United States each year Twenty percent are under age 60. "Being able to screen for a genetic mutation that points to a higher risk will enable us to intervene earlier," says Robert McWilliams, M.D., Mayo Clinic oncologist and lead author of the study. "Early screening is one step in the process to developing ways to prevent or cure this deadly disease."


Nearly all patients who develop pancreatic cancer will succumb to the disease. A genetic marker that helps physicians find individuals most at risk to develop the cancer also will help find it early enough to perform effective surgery. Individuals who carry the cystic fibrosis gene mutation are at increased risk for pancreatitis -- inflammation of the pancreas. Chronic pancreatitis has been proven to increase the risk of pancreatic cancer 26-fold, which led Mayo Clinic researchers to the hypothesis that mutations in the gene that carries cystic fibrosis may be directly linked to a higher risk for pancreatic cancer.

From October 2000 to April 2004, pancreatic cancer patients seen at Mayo Clinic were recruited for the study -- 75 percent of all new patients registered. The pilot study reviewed 33 patients from 41 to 81 years old, with seven having a diagnosis of pancreatitis at least one year prior to cancer diagnosis. Of the 33, a mutation was found in the cystic fibrosis transmembrane conductance regulator (CFTR) gene in two patients, both younger than 60. A follow-up study was designed to test all the young-onset cases in the registry, resulting in a study group of 166 young-onset pancreatic cancer patients. This study showed that mutations in the CFTR gene were present in twice as many young pancreatic cancer patients than in the comparison group, which consisted of all patients tested for CFTR at Mayo Clinic from November 2003 to May 2004.

Further study is needed, and Dr. McWilliams cautions that the overall risk to carriers of cystic fibrosis is still small. However, he and his colleagues say this is a step towards greater understanding of who is at risk for developing pancreatic cancer at a young age. "We are excited about the finding," says Dr. McWilliams, "And we have an additional study underway with more patients to confirm the finding for young patients as well as look at implications for those over age 60."

Other Mayo Clinic researchers involved with this study include: W. Edward Highsmith Jr., Ph.D.; Kari Rabe; Mariza de Andrade, Ph.D.; Larry Tordsen; Leonard Holtegaard; and Gloria Petersen, Ph.D.

Elizabeth Zimmermann | EurekAlert!
Further information:
http://www.mayoclinic.com
http://spores.nci.nih.gov/current/breast/breast.html

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>