One of the isomers of conjugated linoleic acid, a group of fatty acids found in milk, is a natural regulator of the COX-2 protein, which plays a significant role in inflammatory disease such as arthritis and cancer, according to a study published by University of Wisconsin-Madison researchers.
"Its clear from previous research that conjugated linoleic acid, or CLA, prevents inflammatory damage resulting from immune response," says Mark Cook, a professor of animal science in UW-Madisons College of Agricultural and Life Sciences. "Weve identified the biochemical mechanism by which this occurs."
CLA, which is synthesized by microbial fermentation in the rumen of dairy cows, exists naturally in a number of structural forms. Cooks team determined that one of the variants inhibits the COX-2 protein by blocking a key cellular pathway. The COX-2 protein is known to play a significant role in many inflammatory diseases and is an important drug target for treating arthritis and cancer, Cook says.
Mark Cook | EurekAlert!
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