The scientific magazine Brain Research has recently published the results of research work by scientists from the University of Navarra. The work describes the presence and location of the cellular prion protein (PrPC) in the brain of the rat and characterises the neurones expressed therein, above all within the cerebral cortex of this rodent. The authors are José Luis Velayos and Francisco José Moleres, research scientists at the Department of Anatomy at the University of Navarra.
The PrPC is a normal physiological protein, especially present in the central nervous system, including that of the human, with functions that are little known as yet. Altered prionic proteins, pathogens, infectants, i.e. prions, are responsible for spongiform encephalopathies, amongst these being bovine spongiform encephalopathy (BSE or mad cow disease). In order to operate, prions require the presence of the PrPC. Thus, the importance of this investigation for the location of the PrPC in the central nervous system.
Knowing where in the central nervous system the prions operate
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