Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Gene therapy may protect normal tissues during radiation retreatment for lung cancer


Gene therapy could be used as an agent to protect normal tissues, including the esophagus and lung, from damage during a second administration of radiation therapy for non-small cell lung cancer, according to an animal study presented today by University of Pittsburgh researchers at the 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Denver.

"A major challenge in treating lung tumors with radiation is the toxicity of radiation to healthy tissue," said Joel S. Greenberger, M.D., professor, University of Pittsburgh School of Medicine. "This can result in major quality-of-life issues for lung cancer patients receiving radiation therapy for their diseases. In previous studies, we demonstrated that gene therapy may protect healthy tissues from damage prior to an initial course of radiation therapy. In this study, we found that gene therapy also can protect the same healthy tissue during retreatment with radiation." Dr. Greenberger explained that a related study shows the effectiveness of aerosol delivery of this therapy by an inhalation nebulizer making it clinically feasible.

In the study, animal models were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy during exposure to radiation. One group of mice received an intratracheal injection of MnSOD-PL 24 hours before a course of 14 Gy irradiation, while a second group received 14 Gy irradiation alone. The mice were observed for six months for any toxic pulmonary effects and then subdivided into two more groups. One of these groups was exposed to a second lung irradiation of 10 Gy without MnSOD-PL and the other received an injection of MnSOD-PL 24 hours prior to radiation exposure.

The researchers found that in mice that received the initial 14 Gy dose there was 50 percent survival at 180 days (due to lung toxicity) compared to 87.5 percent survival during the same length of time for mice that were injected with MnSOD-PL prior to irradiation. Mice that received MnSOD-PL before both the 14 Gy dose as well as the subsequent 10 Gy dose had the best survival rate overall. Mice treated with MnSOD-PL before the first dose of radiation had a survival rate of 31.6 percent, while mice receiving the treatment before both courses of radiation had a survival rate of 47.6 percent.

"Administration of this type of gene therapy appeared to prevent the damaging effects of radiation, even when the radiation was re-administered after six months," said Dr. Greenberger. "Future studies will tell us whether this therapy can improve the quality of life for lung cancer patients and help us more effectively treat lung cancer without the damaging side effects."

Lung cancer is the leading cause of cancer-related death in men and women. In 2005, more than 170,000 new cases of lung cancer will be diagnosed. Side effects from radiation therapy for lung cancer can include fatigue, skin changes, swelling of the esophagus, hair loss in the treated area, dry cough caused by swelling of the lung tissue and sore throat.

Clare Collins | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

nachricht Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

Modular safety concept increases flexibility in plant conversion

22.03.2018 | Trade Fair News

New interactive map shows climate change everywhere in world

22.03.2018 | Earth Sciences

New technologies and computing power to help strengthen population data

22.03.2018 | Earth Sciences

Science & Research
Overview of more VideoLinks >>>