Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A high fat, low carbohydrate diet improves Alzheimer’s disease in mice

17.10.2005


Study may also have implications for dieters



Mice with the mouse model of Alzheimer’s disease show improvements in their condition when treated with a high-fat, low-carbohydrate diet. A report published today in the peer-reviewed, open access journal Nutrition and Metabolism, showed that a brain protein, amyloid-beta, which is an indicator of Alzheimer’s disease, is reduced in mice on the so-called ketogenic diet.

The report, by Samuel Henderson, from Accera, Inc, Colorado and colleagues from Belgium runs counter to previous studies suggesting a negative effect of fat on Alzheimer’s disease.


"This work supports the premise that key aspects of Alzheimer’s disease can be altered by changes in metabolism. It also highlights the interaction of dietary components and how such components influence the metabolic state", write the authors.

The authors believe that insulin and the related hormone, insulin-related growth factor-1 (IGF-1), are the key players. "Insulin is often considered a storage hormone, since it promotes deposition of fat but insulin may also work to encourage amyloid-beta production."

Richard Feinman, editor of the journal, explains the relation between nutrients: "You might say that fat is the bomb, and insulin (from carbohydrate) is the fuse. Most studies of the deleterious effects of fat have been done in the presence of high carbohydrate. If carbs are high, dietary fat is not oxidized and is instead stored as body fat." When carbohydrates are very low and fat is high, compounds called ketone bodies are generated (ketosis) and these compounds may play a role in the observed reduction in amyloid-beta. In association with a group from University of Washington led by Dr. Suzanne Craft, Henderson has previously shown cognitive improvement in patients with mild AD who were given a diet that raises ketone bodies.

In an accompanying editorial, Feinman says, "Although it is too early to tell how the results will fit into the treatment of AD, the implication for diet in general is also important." The primacy of insulin as a control element is the basis of popular weight-loss diets based on carbohydrate restriction. Such regimens allow dieters to regulate fat and calorie intake by appetite alone as long as carbohydrate intake remains minimal. Feinman points out, "Henderson’s effort is one of several recent studies that point the way to understanding metabolism beyond the issues surrounding simple fat reduction."

Juliette Savin | EurekAlert!
Further information:
http://www.biomedcentral.com

More articles from Life Sciences:

nachricht A room with a view - or how cultural differences matter in room size perception
25.04.2017 | Max-Planck-Institut für biologische Kybernetik

nachricht Studying a catalyst for blood cancers
25.04.2017 | University of Miami Miller School of Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Early organic carbon got deep burial in mantle

25.04.2017 | Earth Sciences

A room with a view - or how cultural differences matter in room size perception

25.04.2017 | Life Sciences

Warm winds: New insight into what weakens Antarctic ice shelves

25.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>