Ensemble of usual sugars offers clues to controlling inflammation
A collaboration led by the Burnham Institute for Medical Research has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohns disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.
Professor Hudson Freeze, Ph.D., director of Burnhams glycobiology and carbohydrate chemistry program, together with staff scientist Geetha Srikrishna, Ph.D., and other colleagues found that a naturally "tweaked" sugar chain normally present on white blood cells and intestinal cells plays a role in inflammation. In addition, the team found that an antibody produced in reaction to the sugars presence curbed intestinal inflammation induced in mice. These findings will be published in the October 15th edition of Journal of Immunology.
Nancy Beddingfield | EurekAlert!
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