Significant for Huntington’s disease and colon cancer
Mayo Clinic researchers have discovered the inner workings of a defective DNA repair process and are first to explain why certain mutations are not corrected in cells. The finding is important because genetic instability and accumulations of mutations lead to disease. This discovery may lead to ways of fixing the process to avoid Huntington’s disease and some types of colon cancer.
The Mayo team discovered that under certain conditions, a key protein fails to recognize a specific form of DNA that it needs to begin the repair process by recruiting additional proteins. They report their findings in a recent issue of Nature Structural and Molecular Biology. (http://www.nature.com/nsmb/journal/v12/n8/pdf/nsmb965.pdf). By failing to initiate repair, the defective mechanism may give rise to disabling inherited brain diseases such as Huntington’s disease, which causes select brain nerve cells to waste away. Huntington’s affects 30,000 adults in the United States, and another 150,000 Americans may be at risk of inheriting it. Friedreich’s ataxia is another neurodegenerative disease that may one day have a treatment based in part on this finding, as could a form of heritable colon cancer (hereditary non-polyposis colon cancer).
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More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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