Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Carnegie Mellon scientists create PNA molecule with potential to build nanodevices

05.10.2005


For the first time, a team of investigators at Carnegie Mellon University has shown that the binding of metal ions can mediate the formation of peptide nucleic acid (PNA) duplexes from single strands of PNA that are only partly complementary. This result opens new opportunities to create functional, three-dimensional nanosize structures such as molecular-scale electronic circuits, which could reduce by thousands of times the size of today’s common electronic devices. The research results will appear in the October 26 issue of the Journal of the American Chemical Society.



"DNA nanotechnology has led to the construction of sophisticated three-dimensional nano-architectures composed exclusively from nucleic acid strands. These structures can acquire a completely new set of magnetic and electrical properties if metal ions are incorporated in the nucleic acids at specific locations because the metal ions have unpaired electrons," said Catalina Achim, assistant professor of chemistry at the Mellon College of Science. "Our goal is to harness the information storage ability of metal-containing PNAs to build molecular-scale devices – tiny replicas of today’s electronic circuit components, such as wires, diodes and transistors."

Normally, DNA occurs as the well-known double helix first proposed by James Watson and Francis Crick 50 years ago. Each strand of the helix consists of a backbone linked to nucleobases, which occupy the inside of the helix. Nucleobases of one strand bind only to specific nucleobases of a complementary strand, and the two strands wind around one another like a twisted ladder. Artificially manufactured PNAs incorporate nucleobases that are bound to a backbone chain of pseudo-amino acids, rather than the sugar-phosphate groups of DNA.


"In modifying our PNAs so that they are significantly more stable, we have discovered that the PNA strands don’t have to be fully complementary for a metal-containing PNA duplex to form. This is an important finding because it should permit us to use non-complementary parts of the PNA duplexes to construct larger structures, which are useful for material science applications," said Achim.

Two years ago, Achim was the first scientist to report the construction of PNA duplexes that contained metal ions (nickel ions, specifically) and ligands inserted in place of a central nucleobases pair. Since then, the researchers, including graduate students and postdocs Richard Watson, Yury Skorik and Goutam Patra, have synthesized PNAs with a variety of ligands and metal ions to broaden the range of thermal stability and electronic properties. By replacing a nucleobase of a PNA with the molecule 8-hydroxyquinoline, which readily binds to copper ions, the research team constructed PNAs whose nucleic acid strands are only partly complementary and found that these duplexes are held together by standard Watson-Crick nucleobase pairs, but also by bonds between copper ions and the 8-hydroxyquinolines projecting from each of the two strands.

Lauren Ward | EurekAlert!
Further information:
http://www.andrew.cmu.edu
http://www.cmu.edu/mcs

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>