Dr. Maki Asano and colleagues have discovered a novel protein motif that regulates Drosophila cell cycle progression by targeting the origin recognition complex (ORC1) for degradation by the ubiquitin ligase, APC. The ORC destruction box, or the "O-box" as is it called, may serve a more widespread role in the proteosomal degradation of various cell cycle factors in other eukaryotes, as well.
This work reveals a heretofore unknown mechanism for the degradation of Drosophila ORC1 by the APC at the end of the M phase of the cell cycle, as well as adding to the short list of previously identified APC targeting motifs (the A-, D-, KEN-, and GXEN-boxes). Further work will be aimed at elucidating the relationship between the O-box and the other destruction sequences in the regulation of proteolysis. Dr. Asano adds that "This work identifies a new signal that flags protein for degradation and we are looking forward to finding additional O-box proteins that may play roles in cell cycle control."
Heather Cosel | EurekAlert!
First time-lapse footage of cell activity during limb regeneration
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Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
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