Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Contagious equine flu virus infecting dogs across U.S. is isolated by Cornell researchers

29.09.2005


A Cornell University virologist has isolated a highly contagious equine flu virus that is spreading a sometimes-fatal respiratory flu among dogs, and is responsible for a major dog-flu outbreak in New York state. There is no evidence that the virus could infect people.



According to a paper published in the Sept. 26 issue of Science Express, the online version of Science magazine, this is the first time an equine flu virus has been found to jump species.

The equine influenza virus, H3N8, was isolated at Cornell’s College of Veterinary Medicine after University of Florida researchers sent fluid and tissue samples from greyhound race dogs that had died from a respiratory illness at a Florida racetrack in January 2004.


"Of all animals, dogs have the most intimate contact with humans on a daily basis, so the potential for human infection has to be in the back of our minds," said Ed Dubovi, director of the virology center at Cornell’s Animal Health Diagnostic Laboratory, who isolated the virus from the University of Florida samples.

Still, he added, there is no evidence of the virus jumping to humans, and there is no expectation of it doing so. It is possible the equine virus has been infecting dogs for some time, although the symptoms are very similar and could be mistaken for common "kennel cough," a bacterial disease related to pertussis (whooping cough) in children. Nevertheless, the paper cautions that the newly discovered flu virus must be closely monitored.

With close to 100 percent of dogs exposed to the virus becoming infected and about 80 percent of infected dogs showing symptoms, the flu could be spreading throughout the country. It was originally documented in greyhounds at tracks and kennels but now is infecting all breeds of dogs. Ongoing testing is being done to track the spread of the virus to different regions of the country.

"Right now, we have a major outbreak of this disease in all breeds of dogs in New York state," said Dubovi, noting that symptoms can include high fever and a respiratory infection that lasts a few weeks, although 1 to 5 percent die from related hemorrhagic pneumonia. From January to May 2005, outbreaks occurred at 20 racetracks in 10 states (Florida, Texas, Arkansas, Arizona, West Virginia, Kansas, Iowa, Colorado, Rhode Island and Massachusetts), according to the paper.

"This infection will become a major concern for all dog owners, since 100 percent of dogs are susceptible to infection by this virus ," said Dubovi. "With 50 million pet dogs in this country, even if you have 1 percent mortality, this is going to result in a number of dogs dying from it."

The Centers for Disease Control and Prevention (CDC) in Atlanta sequenced the virus’ entire genome and found all the segments were from the equine virus. This is unusual, because flu viruses will often swap genetic material with other flu viruses when they jump species. For a new virus to enter another species it must overcome a number of barriers, such as finding a cell receptor to bind to in order to enter the cell and to reproduce sufficiently in the new host.

"There are probably many examples of viruses jumping species, but then it becomes a dead-end issue," said Dubovi. Researchers have long known that equine flu was capable of growing in dogs, since scientists experimenting with equine influenza use cell lines from canine kidney cells.

When Dubovi first received the University of Florida samples, he and his colleagues isolated a virus and determined that it was an influenza not typically found in dogs. The next step was to test to see if it was an avian flu virus, like the virulent H5N1 that has jumped from birds to humans over the last few years. A highly sensitive test -- called a PCR (polymerase chain reaction) that amplifies and detects small amounts of DNA or RNA in a blood or tissue sample -- ruled out avian flu strains H5 and H7.

The isolate was then sent to the CDC where Ruben Donis, Cornell Ph.D. ’87, one of Dubovi’s former graduate students and currently chief of molecular genetics for the influenza branch, found that it tested positive for equine influenza virus. Donis also ruled out the possibility that the sample had been contaminated with equine virus from another source.

The study by lead author, Cynda Crawford, an immunologist at the University of Florida’s College of Veterinary Medicine, was funded by the State of Florida’s Division of Parimutuel Wagering in response to ongoing respiratory problems in racing greyhounds.

Krishna Ramanujan | EurekAlert!
Further information:
http://www.cornell.edu

More articles from Life Sciences:

nachricht 'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society

nachricht New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>