Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Compound reveals new link between signaling protein and cell migration

26.09.2005


University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells. The finding may suggest new pharmaceutical therapies for treating a variety of diseases, including cancer.



The protein, known as Raf Kinase Inhibitor Protein, or RKIP, controls activity of kinases, a type of enzyme that acts as a key component in the biochemical signaling pathways responsible for determining almost all cellular activity. But RKIP’s own activity is inhibited when a small molecule organic compound called locostatin, discovered earlier by UIC researchers, binds to it.

Lead investigator Gabriel Fenteany, assistant professor of chemistry at UIC, reports the finding in the Sept. 26 issue of the journal Chemistry and Biology.


The researchers used an approach sometimes called "forward chemical genetics" whereby they first identified locostatin as an inhibitor of cell migration, then used locostatin itself as a kind of bait to fish out the protein to which it binds. That protein was RKIP.

"We have implicated this protein in controlling cell migration, a role it was not previously known to play," said Fenteany. "It’s a molecular target of locostatin. We found this on the basis of the chemical affinity of locostatin for this protein."

As a regulatory protein, RKIP controls the functions of kinases, thereby governing signaling pathways. When these pathways are not properly controlled, all kinds of diseases can result, including cancer.

Fenteany and his team also confirmed that RKIP is involved in cell migration by using other methods.

"After finding that locostatin targets RKIP, we wanted to verify that RKIP really does control cell migration," Fenteany said. The researchers removed, or knocked down, RKIP in the cell using a method called RNA interference and looked at the effect on cell migration. They did the opposite manipulation as well -- artificially increasing the amount of RKIP in the cell and again looking at the effect on cell migration. In each case, the result was consistent with RKIP having an important, positive role in the control of cell migration.

"The interest in RKIP now is that it is a new and apparently important modulator of cell migration and therefore a possible target in anti-cancer strategies focused on limiting tumor angiogenesis and metastasis," Fenteany said.

More investigation on how exactly RKIP controls cell migration is needed, Fenteany said. UIC researchers are also trying to determine the potential of locostatin as a drug by looking at its effects on different types of cells and tissues.

Paul Francuch | EurekAlert!
Further information:
http://www.uic.edu

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>